Cooperative contributions of structural and functional connectivity to successful memory in aging.

Understanding the precise relation between functional connectivity and structural (white matter) connectivity and how these relationships account for cognitive changes in older adults are major challenges for neuroscience. We investigate these issues using an approach in which structural equation modeling (SEM) is employed to integrate functional and structural connectivity data from younger and older adults ( = 62), analyzed with a common framework based on regions connected by canonical tract groups (CTGs). CTGs (e.