Advanced glycation end products in myocardial reperfusion injury.

Advanced glycation end products (AGEs) are associated with cardiovascular diseases. Whether the AGE levels change during myocardial reperfusion injury is currently unknown. The aim of our study was to investigate the dynamics of AGEs in myocardial reperfusion injury and to discuss potential reasons for these changes.

High resolution electrocardiography in healthy dogs: time domain parameters and comparison of the non-stationary (Wigner distribution) versus standard stationary frequency domain analysis methods.

Fractionated heart activation can be detected as late potentials from surface recordings of signal-averaged electrocardiograms (SA ECG) which are considered as a marker of sustained ventricular tachycardia. For animal studies, reference values in time and frequency domain analyses are essentially missing. In the present study, we have established reference values in SA ECG time domain analysis and time-frequency representation of heart activation in healthy dogs.

[The effect of streptozotocin-induced diabetes in the neonatal period on hepatic mitochondrial bioenergetics in adult rats].

Background: Previous experimental studies focused on the liver mitochondrial bioenergetic changes in diabetes mellitus type I induced in adult animals. Information about the effects of persisting neonataly induced diabetes mellitus type I on the mitochondrial bioenergetics are missing.

Aim: The aim of the study was to assess the degree of diabetes mellitus compensation and parameters of oxidative phosphorylation in rats aged 3 months with DM persisting from neonatal period.

Morphological findings after intracoronary application of endothelin-1 in dog.

Background: Endothelin-1 is a strong vasoconstrictor, high doses of which can cause prolonged vasoconstriction.

Main Purpose: The aim of our study was to investigate as to whether the endothelin-induced vasoconstriction causes irreversible morphological changes in the myocardium in experimental animals and to verify the applicability of this experimental model in the study of the impact of endothelin.

Methods: Fourteen anaesthetized dogs were administered with 400 pmol of endothelin.