Validation of the American Association of Poison Control Centers out of hospital guideline for pediatric diphenhydramine ingestions.

Context: In 2006, the American Association of Poison Control Centers (AAPCC) published an out of hospital guideline for diphenhydramine overdoses in children. This guideline has not been validated.

Objective: Our objective was to determine the incidence of serious clinical effects or use of medical treatments after unintentional diphenhydramine ingestions in children.