Macitentan for the treatment of pulmonary arterial hypertension.

Objective: To review the pharmacology, safety, and efficacy of macitentan.

Data Sources: PubMed, EMBASE, and ClinicalTrials.gov were searched using the terms macitentan and ACT-064992.

Safety of low doses of quetiapine when used for insomnia.

Objective: To evaluate the safety of low doses of quetiapine when used for insomnia.

Data Sources: A literature search was performed using PubMed and EMBASE (January 1990-November 2011) using the terms quetiapine, insomnia, sleep, low-dose, subtherapeutic, safety, and weight gain.

Study Selection And Data Extraction: Two prospective trials were identified that evaluated the effect of quetiapine in primary insomnia.