Publications by authors named "Holly T Sullivan"
Diffuse reflectance spectroscopy can differentiate high grade and low grade prostatic carcinoma.
Annu Int Conf IEEE Eng Med Biol Soc
August 2016
Prostate tumors are graded by the revised Gleason Score (GS) which is the sum of the two predominant Gleason grades present ranging from 6-10. GS 6 cancer exclusively with Gleason grade 3 is designated as low grade (LG) and correlates with better clinical prognosis for patients. GS >7 cancer with at least one of the Gleason grades 4 and 5 is designated as HG indicate worse prognosis for patients.
View Article and Find Full Text PDFSystematic diagnosis of prostate cancer using an optical biopsy needle adjunct with fluorescence spectroscopy.
Annu Int Conf IEEE Eng Med Biol Soc
November 2015
Article Synopsis
- Transrectal ultrasound guided prostate biopsies often miss diagnosing prostate cancer, with 90% of samples being benign, highlighting a need for better targeting of cancerous lesions.
- Researchers developed an optical biopsy needle that uses fluorescence spectroscopy to identify cancer by measuring tissue fluorescence before taking samples.
- The study found that this method achieved high sensitivity (86%) and specificity (87%) in distinguishing between benign and malignant tissues, suggesting it could enhance prostate cancer diagnosis and patient care.
Introduction: Prostate biopsies are usually taken from the peripheral rather than anterior region of the prostate. Consequently, tumors originating from the anterior apical region and transition zones may be under-sampled. We examined whether addition of transrectal anterior biopsy (TAB) would improve efficacy of prostate biopsies.
View Article and Find Full Text PDFIn this prospective, non-randomized phase-I clinical trial, we comparatively studied the performance of six laterally-directed biopsies or the modified fan-shaped biopsies (MFSB), midline sextant biopsies (MB), and transition zone biopsies (TZB) and examine their prostate cancer (PCa) detection rates. A total of 114 patients received combinations of MFSB, MB, and TZB based on prostate gland volume: those ≤15 cc received 8 biopsies; those >15 cc but ≤ 50 cc received 14 biopsies; and those >50 cc received 20 biopsies. The mean prostate-specific antigen (PSA) level, Gleason score, and prostate volume were 8.
View Article and Find Full Text PDFProstate cancer (PCa) has a variable biology ranging from latent cancer to extremely aggressive tumors. Proliferative activities of cancers may indicate their biological potential. A flow cytometric assay to calculate maximum proliferative doubling times (T(max)) of PCa in radical prostatectomy specimens after preoperative in vivo bromodeoxyuridine (BrdU) infusion is presented.
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