An analysis of the use of historical control data in the assessment of regulatory pesticide toxicity studies.

The concurrent control group is the most important reference for the interpretation of toxicity studies. However, pooled information on control animals from independent studies, i.e.

Exploring dental faculty perceptions of current strategies and barriers to retention.

Purpose: The aims of the study were to identify perceived strategies for and barriers to faculty retention and examine differences regarding age, gender, and race.

Methods: Cross-sectional data was captured from the eight author-affiliated dental schools. A Qualtrics survey was emailed to all faculty members at these institutions (1467 possible participants) between November 2021 and February 2022.

Improving Global Health and Nursing's International Influence.

The increasing power and political involvement of nurses globally via international nursing organizations, such as Sigma Theta Tau, International and the International Council of Nurses, as well as in International Health Organizations, like Partners in Health, are discussed in this paper. The voice of nurses, like Holly Shaw at the United Nations, and influence of nurses in leadership positions, like Shelia Davis at Partners in Health, are examples of nurses using increasing power and influence in improving health globally. A brief nursing perspective on power is also included.

Self-selecting peer groups formed within the laboratory environment have a lasting effect on individual student attainment and working practices.

Within the present study, we investigate the lasting effect of laboratory peer group interactions on the end of year attainment of Biosciences and Chemistry students. By asking students to identify who they primarily work with within the laboratory environment and evaluating the interactions through cluster analysis, we identified two main categories of laboratory peer groups: the first long-lived well-established pairings of two students, 'swans', who work together for all or the majority of the laboratory sessions; and the second dynamic fluid groups, 'dolphins', of between three and nine students who work with each other interchangeably. Statistical analysis is presented, which demonstrates that individuals within each laboratory peer group were likely to achieve a similar average mark at the end of the first year of study on the course.

Targeting the Wnt signalling pathway in cancer: prospects and perils.

The Wnt pathway, involved in cancer development and progression, has for a long time been said to be undruggable, owing to its complexity and involvement in stem cell biology. This mindset has shifted in the last few years as new research and insights into the pathway mechanisms specific to tumour cells become apparent, leading to the development of multiple compounds targeting the pathway. In this review, we introduce the Wnt pathway and its connections to cancer biology and therapy resistance.

Nursing and midwifery advocacy to lead the United Nations Sustainable Development Agenda.

The United Nations 2030 Agenda for Sustainable Development was implemented on January 1, 2016 and is composed of 17 Sustainable Development Goals (SDGs) and further delineated by 169 targets. This article offers background information on the 2030 Agenda as it relates to nursing and midwifery, professional organizational initiatives currently advancing the SDGs, the ethos of global citizenship, the urgency to respond to dwindling planetary health, the salience of nursing and midwifery advocacy in SDG attainment, and the myriad opportunities for nurses to lead and collaborate toward realizing these Global Goals. A US-based perspective is employed to underscore the Agenda's relevance to the US nursing workforce and healthcare system.

A high-throughput assay pipeline for specific targeting of frizzled GPCRs in cancer.

Frizzleds (FZDs) are a family of GPCRs controlling key events in all branches of the developmental Wnt signaling pathway. In this capacity these receptors are mostly active prenatally and have only a limited set of functions in the human adult. Numerous cancer types and subtypes were shown to be dependent on aberrant Wnt signaling and FZDs in particular.

Admixture mapping and fine-mapping of birth weight loci in the Black Women's Health Study.

Several genome-wide association studies (GWAS) have identified genetic variants associated with birth weight. To date, however, most GWAS of birth weight have focused primarily on European ancestry samples even though prevalence of low birth weight is higher among African-Americans. We conducted admixture mapping using 2918 ancestral informative markers in 2596 participants of the Black Women's Health Study, with the goal of identifying novel genomic regions where local African ancestry is associated with birth weight.

A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers.

Aberrant WNT signaling underlies cancerous transformation and growth in many tissues, such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired mode of development of targeted therapies against these cancers. Despite the urgent need, no WNT signaling-directed drugs currently exist, and only very few candidates have reached early phase clinical trials.

Multi-ethnic high school students' perceptions of nursing in the USA and Israel: a descriptive quantitative study.

Background: In order to target new recruits or future generation of ethnic minority nurses about their potential fit in nursing, it is necessary to understand their perceptions of the profession. Successful recruitment of high school students into nursing in part requires congruency between perceptions of an ideal career and perceptions of nursing as a career. The purposes of this study were to compare ethnic minority high school students in the USA and in Israel on their perceptions of nursing as a career, and to understand how those perceptions compare to their perceptions of an ideal career.

A pathway for repair of NAD(P)H in plants.

Unwanted enzyme side reactions and spontaneous decomposition of metabolites can lead to a build-up of compounds that compete with natural enzyme substrates and must be dealt with for efficient metabolism. It has recently been realized that there are enzymes that process such compounds, formulating the concept of metabolite repair. NADH and NADPH are vital cellular redox cofactors but can form non-functional hydrates (named NAD(P)HX) spontaneously or enzymatically that compete with enzymes dependent on NAD(P)H, impairing normal enzyme function.

Preparing for an influenza pandemic: model of an immunization clinic in an urban family practice.

Problem Addressed: The surge in patient demand for the H1N1 influenza vaccine during the 2009 pandemic.

Objective Of The Program: To facilitate timely delivery of the 2009 H1N1 influenza vaccine to a family practice population while preserving regular clinic function and to create a model of effective vaccination delivery for future outbreaks.

Program Description: An academic family practice in Toronto, Ont, adopted a process-improvement approach and implemented 3 Saturday stand-alone H1N1 vaccination clinics to accommodate increased demand for the vaccine.

Acoustic and perceptual measurement of expressive prosody in high-functioning autism: increased pitch range and what it means to listeners.

Are there consistent markers of atypical prosody in speakers with high functioning autism (HFA) compared to typically-developing speakers? We examined: (1) acoustic measurements of pitch range, mean pitch and speech rate in conversation, (2) perceptual ratings of conversation for these features and overall prosody, and (3) acoustic measurements of speech from a structured task. Increased pitch range was found in speakers with HFA during both conversation and structured communication. In global ratings listeners rated speakers with HFA as having atypical prosody.

Integrating the core professional values of nursing: a profession, not just a career.

To meet the predicted deficit of more than 1 million nurses by 2020, traditional nursing recruitment must target previously un-recruited populations, as well as a culturally diversified workforce to include variations in age, ethnicity, gender, life style, national origin, and sexual orientations. As diversity increases, differences must be bridged to acculturate new nurses to recognize and identify with a shared nursing ideology and culture. The core professional nursing values (CPNVs) impart a common foundation that unites students and nurses in a meaningful, collective culture.

Urban high school students' perceptions of nursing as a career choice.

One hundred and fourteen high school students (n = 114) completed the Attitudes, Values, and Beliefs Questionnaire. A two-sided Wilcoxon Signed Ranks test revealed that students perceived an ideal career as having more power, more positive evaluation, and less activity than a career in nursing would. The areas of greatest perceived disparity and those that showed nursing less favorably were making decisions for one's self, always having a job, working in a safe place, making a lot of money, and earning appreciation and respect.