Publications by authors named "Holly L Nichols"
Article Synopsis
- * This research created the Mosquito-Associated Isolate Collection (MosAIC) with 392 bacterial isolates and their genomic data to provide more detailed information than previous studies, which mainly relied on basic genetic markers.
- * The study also analyzed specific bacterial genera and discovered gene clusters linked to mosquito host interactions, paving the way for future research on how these bacteria affect mosquito behavior and disease transmission.
Unlabelled: Bacteria shape interactions between hosts and fungal pathogens. In some cases, bacteria associated with fungi are essential for pathogen virulence. In other systems, host-associated microbiomes confer resistance against fungal pathogens.
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- - Host genetic variation affects the relationship between insects and their microbial symbionts, with immune responses influencing symbiont density in pea aphids and their associated bacteria, Regiella insecticola.
- - Research shows that aphids adapted to different hosts display distinct immune responses; notably, Trifolium biotype aphids do not downregulate immune genes when harboring Regiella and maintain lower symbiont densities.
- - The findings suggest that while Regiella can suppress immune responses to survive and thrive within aphids, some host populations have evolved mechanisms to resist this suppression, indicating an ongoing evolutionary battle between hosts and their microbial partners.
Evolutionary arms races are broadly prevalent among organisms including bacteria, which have evolved defensive strategies against various attackers. A common microbial aggression mechanism is the type VI secretion system (T6SS), a contact-dependent bacterial weapon used to deliver toxic effector proteins into adjacent target cells. Sibling cells constitutively express immunity proteins that neutralize effectors.
View Article and Find Full Text PDFPurpose: To evaluate the feasibility of a respiratory-gated noncontrast magnetic resonance angiography (MRA) sequence for imaging the central veins of the chest.
Materials And Methods: Eleven healthy subjects underwent MRA of the central veins of the chest with a respiratory-gated noncontrast (SPACE) sequence. Qualitative visualization and signal homogeneity of each central venous segment were scored by two radiologists on a scale of 1-4.