Publications by authors named "Holly L Bond"
J Cell Physiol
January 2025
Article Synopsis
- The study focuses on idiopathic inflammatory myopathies (IIMs), which are characterized by overexpression of MHC I on muscle fibers and a distinct type I interferon (IFN) signature.
- Researchers investigated how elevated MHC-I and type I IFNs affect mitochondrial function in human skeletal muscle myoblasts, finding that MHC-I overexpression led to decreased mitochondrial respiration and other impairments, made worse when combined with IFNs.
- The findings suggest that while MHC-I alone does not increase reactive oxygen species (ROS), the addition of type I IFNs does, indicating a synergistic effect that may have important implications for understanding the mechanisms behind myositis.
