Publications by authors named "Holly Hope"
Objectives: To detail the relationship between parental mental illness and the likelihood of out-of-home care (OHC) among their children, and to identify factors which modify this relationship.
Methods: Using Swedish national registers, children born in 2000 to 2011 (n = 1 249 463) were linked to their parents. Time-dependent parental mental illness (nonaffective and affective psychosis, substance misuse, depression, anxiety and stress, eating disorders, personality disorders, attention deficit hyperactivity disorder, autism, and intellectual disability), was identified through International Classification of Diseases codes.
Background: To address if the long-standing association between maternal infection, depression/anxiety in pregnancy, and offspring neurodevelopmental disorder (NDD) is causal, we conducted two negative-control studies.
Methods: Four primary care cohorts of UK children (pregnancy, 1 and 2 years prior to pregnancy, and siblings) born between 1 January 1990 and 31 December 2017 were constructed. NDD included autism/autism spectrum disorder, attention-deficit/hyperactivity disorder, intellectual disability, cerebral palsy, and epilepsy.
Background: There are increasing concerns that participants in health research in the UK are not representative of the UK population, risking widening health inequities. However, detailed information on the magnitude of the problem is limited. Therefore, we evaluated if the health research conducted in the Greater Manchester region was broadly representative of its diverse population.
View Article and Find Full Text PDFDetection and evaluation of signals associated with exposure to individual and combination of medications in pregnancy: a signal detection study protocol.
BMJ Open
October 2023
Article Synopsis
- The study addresses the issue of polypharmacy in pregnant women, highlighting the need for more research on the safety of their complex medication plans, particularly focusing on adverse and protective effects of various medications during pregnancy.
- It employs real-world data from the UK to conduct a pharmacovigilance study assessing medication safety in women during the preconception period and the first trimester.
- A multidisciplinary expert team will analyze and reach consensus on the signals of associations between medication exposure and pregnancy outcomes to filter out misleading data for further evaluation.
Importance: Adversity during childhood can limit children's chances of achieving their optimal developmental and psychological outcomes. Well-designed observational studies might help identify adversities that are most implicated in this, thereby helping to identify potential targets for developing interventions.
Objective: To compare the association between preventing childhood poverty, parental mental illness and parental separation, and the population rate of offspring common mental disorders (ages 16-21 years) or average school grades (age 16 years).
Background: The number of children exposed to maternal mental illness is rapidly increasing and little is known about the effects of maternal mental illness on childhood atopy.
Aim: To investigate the association between maternal mental illness and risk of atopy among offspring.
Design And Setting: Retrospective cohort study using a UK primary care database (674 general practices).
Background: Few studies have investigated the effect of the COVID-19 pandemic on mental health beyond 2020. This study quantifies changes to healthcare utilisation and symptoms for common mental health problems over the pandemic's first 21 months.
Methods: Parallel cohort studies using primary care database and survey data for adults (≥16 years) in England from January 2015 to December 2021: 16,551,842 from the Clinical Practice Research Datalink (CPRD) and 40,699 from the UK Household Longitudinal Survey (UKHLS).
Article Synopsis
- This study developed a core outcome set for future research on pregnant women with multimorbidity to tackle issues of inconsistent outcome reporting across studies.
- The development process involved a systematic literature search, focus groups, and Delphi surveys engaging diverse stakeholders, including affected women and healthcare professionals.
- The final core outcome set identified 11 key outcomes, including maternal death, severe morbidity, and baby survival rates, which should be consistently measured in related research.
Article Synopsis
- A qualitative study was conducted to identify important outcomes for pregnant women with multiple long-term health conditions by involving women, their partners, and healthcare professionals in focus groups.
- The study found 63 outcomes related to maternal health, child health, and healthcare utilization, with new outcomes discovered that haven't been previously emphasized in the literature.
- Participants highlighted the importance of care processes, particularly the need for effective information sharing during transitions in healthcare, showing a consensus on the significance of various outcomes across different stakeholders.
Objective: Caring for a child with cystic fibrosis (CF) is a rigorous daily commitment for caregivers and treatment burden is a major concern. We aimed to develop and validate a short form version of a 46-item tool assessing the Challenge of Living with Cystic Fibrosis (CLCF) for clinical or research use.
Design: A novel genetic algorithm based on 'evolving' a subset of items from a pre-specified set of criteria, was applied to optimise the tool, using data from 135 families.
Article Synopsis
- * Researchers will analyze data from UK health records spanning from 2000 to 2019, examining various health outcomes during different stages: antenatal, peripartum, postnatal, and long-term mental health.
- * Ethical approval has been secured, and findings are set to be published in peer-reviewed journals and presented at major conferences for wider dissemination.
Article Synopsis
- The study looks at how many pregnant women are taking multiple medications, which has become more common over the last 20 years.
- It gathered data from a big medical records database to see how often women used 2 or more medicines during pregnancy.
- The findings show that about 25% of women used multiple medications in their first trimester, and some risk factors for this include being overweight, from certain ethnic groups, or being a smoker.
Article Synopsis
- - Antipsychotic prescriptions for children and adolescents have been on the rise globally, prompting a study on prescribing trends and reasons for prescriptions in a large English cohort from 2000 to 2019.
- - Using a primary care database (CPRD Aurum), researchers tracked 7,216,791 children and adolescents, identifying 19,496 individuals who received 243,529 antipsychotic prescriptions while analyzing trends by age, gender, and socio-economic status.
- - The study employed an algorithm to determine likely reasons for initial prescriptions due to a lack of direct indication data, highlighting clinical preferences for different types of antipsychotics across varying deprivation levels.
Article Synopsis
- Pregnancy complications like pre-eclampsia and gestational diabetes usually get better after childbirth, but they can lead to long-term health risks for women, such as heart disease.
- This study will look at different reviews to see how pregnancy problems are connected to five types of long-term health issues, including autoimmune diseases, cancers, and mental health issues.
- The researchers will analyze lots of studies to understand these links better and share the results, helping to create predictions for women's future health risks.
The purpose of this study is to characterise the sexual and reproductive health risks associated with mental illness among women. This was a retrospective cohort study of 2,680,149 women aged 14 to 45 years in the Clinical Practice Research Datalink, a UK primary care register, linked to 1,702,211 pregnancies that ended between the 1st January 1990 and 31st December 2017. Mental illness was identified in primary care and categorised into the following: common mental illness (depression/anxiety); addiction (alcohol/drug misuse); serious mental illness (affective/non-affective psychosis); other mental illness (eating/personality disorders).
View Article and Find Full Text PDFIntroduction: Improving the lives of children and adolescents with parental mental illness (CAPRI) remains an urgent political and public health concern for the UK and European Union. Recurrent parental mental illness is believed to lead to fractures in the family, academic and social lives of these children, yet interventions are poorly targeted and non-specific. Part of an interdisciplinary programme of work (the CAPRI Programme; grant number: 682741), CAPRI-Voc aims to achieve two goals: first, to test the feasibility of our longitudinal imaging paradigm in mother-infant pairs where the mother has a diagnosis of severe mental illness.
View Article and Find Full Text PDFObjective: Treatments for cystic fibrosis (CF) are complex, labour-intensive, and perceived as highly burdensome by caregivers of children with CF. An instrument assessing burden of care is needed.
Design: A stepwise, qualitative design was used to create the CLCF with caregiver focus groups, participant researchers, a multidisciplinary professional panel, and cognitive interviews.
Background: Perinatal self-harm is of concern but poorly understood.
Aims: To determine if women's risk of self-harm changes in pregnancy and the first postpartum year, and if risk varies by mental illness, age and birth outcome.
Method: This was a retrospective cohort study of 2 666 088 women aged 15-45 years from the 1 January 1990 to 31 December 2017 linked to 1 102 040 pregnancies and their outcomes, utilising the Clinical Practice Research Datalink and Pregnancy Register.
Background: Although maternal death is rare in the United Kingdom, 90% of these women had multiple health/social problems. This study aims to estimate the prevalence of pre-existing multimorbidity (two or more long-term physical or mental health conditions) in pregnant women in the United Kingdom (England, Northern Ireland, Wales and Scotland).
Study Design: Pregnant women aged 15-49 years with a conception date 1/1/2018 to 31/12/2018 were included in this population-based cross-sectional study, using routine healthcare datasets from primary care: Clinical Practice Research Datalink (CPRD, United Kingdom, n = 37,641) and Secure Anonymized Information Linkage databank (SAIL, Wales, n = 27,782), and secondary care: Scottish Morbidity Records with linked community prescribing data (SMR, Tayside and Fife, n = 6099).
Background: The general health of children of parents with mental illness is overlooked.
Aims: To quantify the difference in healthcare use of children exposed and unexposed to maternal mental illness (MMI).
Method: This was a retrospective cohort study of children aged 0-17 years, from 1 April 2007 to 31 July 2017, using a primary care register (Clinical Practice Research Datalink) linked to Hospital Episodes Statistics.
Importance: Infection with SARS-CoV-2 is associated with fatigue and sleep problems long after the acute phase of COVID-19. In addition, there are concerns of SARS-CoV-2 infection causing psychiatric illness; however, evidence of a direct effect is inconclusive.
Objective: To assess risk of risk of incident or repeat psychiatric illness, fatigue, or sleep problems following SARS-CoV-2 infection and to analyze changes according to demographic subgroups.
Article Synopsis
- The study focuses on developing a core outcome set (COS) for maternal and offspring health in pregnant women who have pre-existing multimorbidity, which may negatively impact health outcomes.
- It employs a four-stage design: a systematic literature search, focus groups for personal insights, a Delphi survey for prioritization, and a consensus meeting to finalize the outcomes.
- Ethical approval has been granted by the University of Birmingham, ensuring the study follows proper ethical guidelines and will effectively gather and disseminate relevant findings.
Background: The mental health of the UK population declined at the onset of the COVID-19 pandemic. Convenience sample surveys indicate that recovery began soon after. Using a probability sample, we tracked mental health during the pandemic to characterise mental health trajectories and identify predictors of deterioration.
View Article and Find Full Text PDFBackground: The COVID-19 pandemic has adversely affected population mental health. We aimed to assess temporal trends in primary care-recorded common mental illness, episodes of self-harm, psychotropic medication prescribing, and general practitioner (GP) referrals to mental health services during the COVID-19 emergency in the UK.
Methods: We did a population-based cohort study using primary care electronic health records from general practices registered on the UK Clinical Practice Research Datalink (CPRD).
Background: Children of parents with mental illness are a vulnerable group, but their numbers and their exposure to adversity have rarely been examined. We examined the prevalence of children with parents with mental illness in Sweden, trends in prevalence from 2006 to 2016, and these children's exposure to socioeconomic adversity.
Methods: We did a population-based cohort study among all children (aged <18 years) born in Sweden between Jan 1, 1991, and Dec 31, 2011, and their parents, followed up between Jan 1, 2006, and Dec 31, 2016.