Publications by authors named "Holly G Bray"
Biochemistry
October 2013
Article Synopsis
- The study explores how the short cytoplasmic tails of α- and β-integrin chains influence integrin activation and signaling, with a focus on proteins that bind to α-integrin cytoplasmic tails (CTs).
- Previous research identified calcium and integrin binding protein 1 (CIB1) as a key inhibitor of the αIIbβ3 integrin, highlighting a conserved binding site for CIB1 across all α-integrins.
- The findings suggest that CIB1 can interact with multiple α-integrin CTs and may function as a universal regulator of integrin activity, supported by experimental binding assays and molecular modeling techniques.
