Publications by authors named "Holly Eager"
Hairy cell leukemia (HCL), similar to its variant HCLv, is a B-cell malignancy associated with decreased humoral immunity. We prospectively monitored the largest cohort of patients with HCL/HCLv to date (n = 503) for COVID-19 by symptoms, antibody, and polymerase chain reaction (PCR) and/or antigen positivity. Fifty percent (253 of 503) of the patients with HCL/HCLv (238 HCL and 15 HCLv) had evidence of COVID-19, with 210 (83%) testing positive by PCR or rapid-antigen test.
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- Immune aplastic anemia (AA) involves the loss of certain HLA class I alleles in bone marrow cells, which may help these cells evade destruction by T-cells.
- In a study of 544 AA patients, about 22% showed HLA class I allele loss, with specific alleles like HLA-B*14:02 being most frequently affected, indicating potential links to clinical outcomes and treatment responses.
- The research suggests that HLA genotyping and monitoring for HLA loss could improve the management of immune AA, highlighting unique immune mechanisms and their clinical significance.