Publications by authors named "Holly Corkill"
Objectives: To describe the trend in plasma renin activity over time in patients undergoing cardiac surgery on cardiopulmonary bypass, and to investigate if increased plasma renin activity is associated with postcardiopulmonary bypass vasoplegia.
Design: A prospective cohort study.
Setting: Patients were enrolled from June 2020 to May 2021 at a tertiary cardiac surgical institution.
Article Synopsis
- CCN2 is crucial for osteoblast differentiation and function, stimulated by TGF-β1, with a lesser-known role for AFAP1 in this process.
- AFAP1 expression in osteoblasts varies, peaking as cells proliferate and again during mineralization, and is upregulated by TGF-β1.
- The study shows that AFAP1 is necessary for Src activation and CCN2 induction in response to TGF-β1, suggesting it plays a key role in producing extracellular matrix components like collagen XIIa.