[Effect of fluvastatin on serum lipid levels in essential hypertension].

The efficacy and safety of the HMG-CoA reductase fluvastatin was investigated in a multicenter, open label clinical therapeutic trial in the treatment of hypercholesterinaemia in hypertensive patients (WHO I-II.). 49 patients were involved, 6 patients were dropped out because of th lack of compliance, 43 patients were investigated (mean age: 57.

Interaction of taxol and other anticancer drugs with alpha-cyclodextrin.

The interaction between 23 anticancer drugs and alpha-cyclodextrin (alpha-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. As alpha-CD has smaller cavity than beta- and tau-CD it interacted only with 10 anticancer drugs proving the relatively poor complex forming capacity of alpha-CD. The hydrophobicity of host-guest inclusion complex was always different from that of the uncomplexed drug suggesting that the complex formation may influence the uptake, absorption, half-life etc.

Hungarian Isradipine Study (HIS): long-term (3-year) effects on blood pressure and plasma lipids.

These are the preliminary data of an open multicenter trial of antihypertensive treatment with isradipine as monotherapy (dose, 4.55 +/- 0.56 mg twice daily; n = 11) or isradipine (7.

Interaction of amino acids with a non-homologous series of anticancer drugs.

The interaction of amino acids with 14 commercial anticancer drugs was studied by charge-transfer reversed-phase thin-layer chromatography and the retention matrix was evaluated by principal component analysis. The majority of amino acids had a negligible effect on the retention of anticancer drugs. Only dicarboxy amino acids and Trp exerted a considerable impact on the retention of drugs, indicating the involvement of hydrophilic forces (probably hydrogen bond formation) and stacking interactions in the binding of drugs to amino acids.

Long-term antihypertensive therapy with guanfacine.

Twenty patients with essential hypertension were treated with guanfacine given in single 1-5 mg daily doses over a period of 24 weeks. Compared with the initial values at the end of the first washout period, there was a significant decrease in blood pressure and heart rate. The most common side effect, dryness of the mouth, usually disappeared after 8-10 weeks of treatment.

Antihypertensive effect of guanfacine: long-term 'once-a-day' treatment and sudden withdrawal.

1. Twenty patients with essential hypertension were treated with guanfacine given in single daily doses of 1--5 mg over a period of 24 weeks. Compared with the initial values at the end of the first wash-out period, there was a significant decrease of blood pressure and heart rate.

Denitrification and removal of heavy metals from waste water by immobilized microorganisms.

Pseudomonas fluorescens, immobilized on soft polyvinyl chloride granules containing up to 35% softeners as carbon source, was used for simultaneous removal of nitrate and heavy metals. In typical continuous column operation, a 100 mg/L nitrate input solution was reduced to a 20 mg/L output at a feeding rate of 1500 mL/h, with a capacity of 14 kg/day/m(3), and with an efficiency of 79%. In the same column, Pb(NO3)2 concentration was reduced from 1.

[Electrodynamic discrepancy of the heart].

Electrodynamic discrepancy was observed in the hearts of 15 out of 144 patients with myocardial infarction who died on account of various complications. Autopsy revealed cardiac rupture with pericardial tamponade in each of the 15 cases. If the ECG shows no typical signs of a myocardial infarction, then with great probability an aortic rupture is present.

[Bouquet qualification of wines by gas chromatography. 2. Development of measuring unit for bouquet qualification by determination of relationship of chromatographic peak areas and conditions of application].

In a previous paper we described a method by which routine head-space analysis of wines can be performed with sufficiently accurate results by means of gas chromatography. From the results thus obtained, with application of organoleptic data, chemical and classical analytical parameters of aromatic changes during seasoning and storing wines as well as mathematical-statistical data of the method elaborated, a mathematical relationship has been derived between gas chromatographic peak areas characteristic of different aroma components and the bouquet of wine. Reliability of the method has been verified by the fact that, in spite of the small number of samples, the bouquet of seven different types of wine could be discriminated in 95,45% probalility.

[Bouquet qualification of wines by gas chromatography. 1. Experimental method for gas phase analysis].

In the course of our investigations we tried to find a method for the bouquet qualification of wines by gas chromatography. For this purpose, instead of aroma research studies requiring complex equipment and laboursome precise laboratory work, we developed a method for head space analysis functioning with simple experimental instruments and being sufficiently fast for serial routine work. By the method developed, the head space of a great number of samples taken from 7 different wine-types have been successfully examined.