Does a multidisciplinary menopausal symptoms after cancer clinic reduce symptoms?

Purpose: This study aimed to measure the prevalence of menopausal symptoms in patients attending a multidisciplinary model of care clinic at their initial clinic visit and their subsequent follow-up consultation using a validated patient-reported outcome measure to assess whether menopausal symptoms after cancer had improved.

Methods: A retrospective review was conducted of patients attending the clinic in a 12-month period in 2017 (n = 189). Recorded variables included patient demographics, details of index cancer, previous treatments, and menopausal symptom management strategies.

Advanced Training of Gynecologic Surgeons and Incidence of Intraoperative Complications after Total Laparoscopic Hysterectomy: A Retrospective Study of More Than 2000 Cases at a Single Institution.

Study Objective: To investigate whether surgeon factors including level of training undertaken in laparoscopic surgery, time in specialist practice, and case volume were associated with surgical morbidity for total laparoscopic hysterectomy (TLH).

Design: A retrospective cohort study (Canadian Task Force classification II-2).

Setting: A tertiary care setting in Western Australia.

Time to delivery: Transfers for threatened preterm labour and prelabour rupture of membranes in Western Australia.

Objective: To describe the outcomes of patients transferred to King Edward Memorial Hospital (KEMH) with signs of labour at preterm gestations.

Design: A retrospective observational study of the 69 cases transferred to KEMH during 2015.

Setting: Patient transfers from all locations across Western Australia (WA) to the sole tertiary perinatal centre in Perth.

Enhanced Sanitation Standard Operating Procedures Have Limited Impact on Listeria monocytogenes Prevalence in Retail Delis.

In a recent longitudinal surveillance study in 30 U.S. retail delicatessens, 9.

Is gynaecological surgical training a cause for concern?: a questionnaire survey of trainees and trainers.

Background: Concerns have been raised as to whether the current postgraduate training programme for gynaecological surgery is being detrimentally affected by changes in working practices, in particular the European Working Time Directive (EWTD). The purpose of this study was to investigate the surgical activity of obstetrics and gynaecology trainees and to explore trainees' and trainers' opinions on the current barriers and potential solutions to surgical training.

Methods: Two questionnaire surveys were conducted, one to obstetrics and gynaecology trainees working within the West Midlands Deanery and a second to consultant gynaecologists in the West Midlands region.

The use and understanding of CA125 as a tumor marker for ovarian cancer: a questionnaire-based survey.

The aim of this study was to assess the level of understanding of the role of the tumor marker CA125 in ovarian cancer among doctors of different grades specializing in obstetrics and gynecology (O&G), medicine, surgery, and primary care (general practitioners [GPs]). The study involves a questionnaire-based survey. Two hundred and fifty-nine questionnaires were distributed.

What happens to women with chronic pelvic pain after a negative [normal] laparoscopy?

Chronic pelvic pain remains unexplained in one third of women who have negative [normal] findings at diagnostic laparoscopy. This paper investigates the history of chronic pelvic pain after a negative laparoscopy and to assess the effect of negative laparoscopy on self perceived quality of life. The results of this study show that chronic pelvic pain persists in the majority of women who had negative laparoscopy in the medium to long term.

The role of CA125 in clinical practice.

Background: CA125 is a high molecular weight glycoprotein, which is expressed by a large proportion of epithelial ovarian cancers. The sensitivity and specificity of CA125 are poor and there are no guidelines produced by the Royal College of Pathologists or the Association of Clinical Biochemists to aid clinicians and laboratories in its most appropriate use.

Aim: To identify the patient population having a CA125 measurement and to determine its contribution to individual patient management.

Functional analysis of tomato Pti4 in Arabidopsis.

Pti4 is a tomato (Lycopersicon esculentum) transcription factor that belongs to the ERF (ethylene-responsive element binding factor) family of proteins. It interacts with the Pto kinase in tomato, which confers resistance to the Pseudomonas syringae pv tomato pathogen that causes bacterial speck disease. To study the function of Pti4, transgenic Arabidopsis plants were generated that expressed tomato Pti4 driven by the strong constitutive promoters, cauliflower mosaic virus 35S and tCUP.

Wave propagation in one-dimensional optical quasiperiodic systems.

One-dimensional quasiperiodic optical systems are studied, using a Schrödinger-like equation with a potential V(x)=2lambda(1) cos x+2lambda(2) cos alphax as an approximation to the wave equation in the slowly-varying wave approximation. It is shown that small changes in the parameter alpha produce major changes in the band structure of the system. For certain values of alpha, the band structure consists of many "thin bands" and allows the possibility of dense multiplexing.

Does histological incomplete excision of cervical intraepithelial neoplasia following large loop excision of transformation zone increase recurrence rates? A six year cytological follow up.

Objective: To determine the risk of recurrent cervical intraepithelial neoplasia (CIN) in women with complete or incomplete excision of cervical intraepithelial neoplasia treated by large loop excision of transformation zone (LLETZ).

Design: A retrospective study

Setting: One consultant-led colposcopy clinic at Leicester Royal Infirmary

Population: Three hundred and ninety-four women referred consecutively to the colposcopy clinic between 1991 and 1992.

Main Outcome Measures: The histological recurrence rate of CIN, length of cytological follow up following treatment related to degree of completeness of excision at initial treatment.

Cervical disease in women referred to colposcopy following inadequate smears.

The aim of this audit was to determine if inadequate cervical smears are associated with significant cervical pathology. Case records for 52 women with three consecutive inadequate smears referred for colposcopy to the Leicester Royal Infirmary (LRI) were retrieved. Sixteen women underwent large loop excision of the transformation zone (LLETZ) and cervical intraepithelial neoplasia (CIN) was identified in six cases.

Endodermal sinus tumour of the ovary in pregnancy.

We present a case of a 30-year-old pregnant woman in whom an ovarian mass was identified by ultrasonography at 15 weeks' gestation. A markedly elevated maternal serum alphafetoprotein (MSAFP) suggested a diagnosis of endodermal sinus tumour of the ovary. A right salpingo-oophorectomy at 19 weeks' gestation enabled histological confirmation of the diagnosis and suggested a stage 1 tumour.

Resonant photoemission from complex cuprates and nickelates.

Synchrotron-excited resonant-photoemission measurements at rare-earth 4d --> 4f and transition-metal 3p --> 3d thresholds have been carried out using a variety of complex cuprates and nickelates on stations 6.1 (grazing-incidence monochromator) and 6.2 (toroidal-grating monochromator) at the SRS CLRC Daresbury Laboratory.

Anti-CD3 and anti-cd16 monoclonal-antibody in-vitro enhancement of NK activity in pbl from gastrointestinal-tract cancer-patients.

Natural killer (NK) cell cytotoxicity was assessed using peripheral blood mononuclear cells from 103 healthy volunteers and 51 cancer patients. Peripheral blood cells were assessed by flow cytometry, and cytotoxicity in a standard 4-hour Cr-51-release assay using K562 cells as targets. Anti-CD3 and anti-CD16 mAb significantly enhanced cytoxicity in vitro.

The effect of low-dose okt3 monoclonal-antibody therapy on k562 cytotoxicity in human cancer-patients.

Low concentrations of monoclonal antibodies (mAb) specific for the CD3 component of the T cell receptor complex (TcR) may be both immunosuppressive or potent activators of T cell function in vitro depending upon the experimental situation. The anti-CD3 mAb OKT3 is imnmunosuppressive at high doses (5 mg/day for 10 to 14 days) in transplant patients. We undertook a preliminary study to investigate the effect of a single intravenous injection of 50 mu g to 0.

Combined interleukin-2 and okt3 therapy in the treatment of metastatic melanoma.

Objective tumour responses have been documented in patients with malignant melanoma following therapy with recombinant interleukin-2 (rIL-2). Recent attempts to reduce toxicity and retain therapeutic efficacy of rIL-2 have involved low-dose subcutaneous rIL-2 administration and the exploration of synergy with other agents. The anti-CD3 monoclonal antibody OKT3 (Cilag), is immunosuppressive when given at high doses.

Ruptured mycotic aneurysm of the abdominal aorta in childhood.

Aortic aneurysms are exceedingly rare in childhood and, when mycotic, the risk of rupture is high. We report a case of ruptured mycotic abdominal aortic aneurysm presenting in a 9 year old girl, that was successfully repaired after initial misdiagnosis.

The treatment of colorectal hepatic metastases by continuous local infusion of interleukin-2.

Patients with hepatic metastases from colorectal cancer appear to be resistant to most forms of therapy. Recent reports suggest synergism between systemically administered recombinant interleukin-2 (rIL-2) and 5-fluorouracil (5-FU) with responses documented in the treatment of advanced colonic tumours albeit with significant toxicity. Local continuous infusion of rIL-2 into selected sites may reduce toxicity and increase efficacy.