Induction of depression with oxotremorine in patients with Alzheimer's disease.

Cholinergic neurotransmission has long been implicated in the development of depression. In this study seven patients with Alzheimer's disease were given oral oxotremorine, a long-acting cholinergic agonist, to assess the drug's effects on cognitive function. There were unexpected depressive reactions in five of the seven patients; three patients dropped out of the study because of the side effects.

Antemortem markers of Alzheimer's disease.

This review examines various approaches to the development of antemortem markers of Alzheimer's disease. Among the procedures discussed are: neurochemical and histopathologic studies of the cholinergic system, concentrating on CSF and blood plasma; genetic studies; imaging and electrophysiological studies; and neuroendocrine studies.

Effect of apomorphine infusion on plasma homovanillic acid in normal subjects.

Previous experiments suggest that pharmacological perturbations of the brain dopaminergic system may be reflected by concentrations of plasma homovanillic acid. This study examined the ability of apomorphine infusion to reduce plasma homovanillic acid concentrations in normal subjects. The data suggests that apomorphine does not reduce plasma homovanillic acid concentration.

Separate mechanisms for behavioral, cardiovascular, and hormonal responses to dextroamphetamine in man.

The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.

[Disorders of electrolyte balance and metabolism in hormone-secreting bronchial cancer].

Four cases of bronchial carcinoma were observed which showed the picture of an ectopic ACTH-hormone syndrome. References to an endocrinopathy resulted from the hypopotassaemia and the metabolic alkalosis. Signs of Cushing's syndrome appeared only in one case.