The haemodynamic effects of flunitrazepam in anaesthetized patients with valvular or coronary artery lesions.

The Haemodynamic effects of flunitrazepam (FLU) 1.25 mg X m-2 administered intravenously were studied in 18 anaesthetized cardiac patients suffering from isolated mitral (MIT, n = 6), aortic (AOR, n = 6) or coronary (COR, n = 6) lesions. A placebo group of 18 clinically similar patients was used to assess the stability of the cardiovascular parameters under the conditions of the study.

Age-dependent dose-response relationship of ORG NC 45 in anaesthetized patients.

The effects of age on the dose of Org NC 45 were studied in 24 healthy, anaesthetized patients using an on-demand infusion of the drug which produced a stable twitch height of 10% of its initial value. The patients were allocated as follows: group I = age less than 40 yr; group II = 40-60 yr and group III = age greater than 60 yr. A steady-state dose measured every 10 min, was achieved in all the patients 30 min after the start of the administration of Org NC 45.

Circulation and function of human platelets isolated from units of CPDA-1, CPDA-2, and CPDA-3 anticoagulated blood and frozen with DMSO.

Platelet concentrates (PC) were isolated by serial differential centrifugation from units of blood anticoagulated with one of the citrate-phosphate-dextrose-adenine solutions (CPDA-1, CPDA-2, CPDA-2). The platelet concentrates were frozen with six percent dimethylsulfoxide at 2-3 degrees C per minute and stored in a -80 degrees C mechanical freezer in polyvinyl chloride or polyolefin plastic containers. After frozen storage at -80 degrees C for up to three months, the concentrates were thawed at 42 degrees C within 2.

Stable muscle relaxation during abdominal surgery using combined intravenous bolus and demand infusion: clinical appraisal with ORG NC45.

In order to obtain stable muscle relaxation for intra-abdominal operation, a continuous demand perfusion of ORG NC45 was administered following a loading dose of 0.07 mg . kg-1.

Evolution of single twitch and train-of-four responses and of tetanic fade in relation to plasma concentrations of fazadinium in man.

The evolution of single twitch and train-of-four (2 Hz) responses and tetanic fade (100 Hz) in relation to plasma concentration of fazadinium was determined during stable anesthesia (fentanyl-N2O) in six healthy adult patients after a bolus injection of 0.75 mg/kg of fazadinium. The interval between injection and 50% recovery and the corresponding fazadinium plasma concentrations were (mean +/- SEM): 47 +/- 4 minutes and 1.

Echocardiographic dimensions and maximal oxygen uptake in oarsmen during training.

We studied nine freshmen and 14 senior oarsmen undergraduates during seven months of training and compared them with 17 age and sex-matched sedentary control subjects in order to assess the influence of heavy physical exercise on cardiac dimensions and maximal oxygen uptake. Standard M-mode echocardiographic techniques were used. At the start of the season senior oarsmen had a greater left ventricular end-diastolic dimension, and a thicker interventricular septum and posterior left ventricular wall than control subjects and freshmen oarsmen.

Relationship between decay of plasma concentration of fazadinium and recovery from its neuromuscular blocking effect.

The relationship of the time-course of the decay of plasma concentration of fazadinium and neuromuscular block has been investigated after i.v. administration of 0.

Haemodynamic changes associated with atropine/neostigmine administration. A non-invasive investigation.

Stroke volume, systolic time intervals and related index variations induced by atropine/neostigmine (AN) (0.75 mg/l mg) decurarization mixture were investigated by non-invasive methods (ECG, phonocardiogram, thoracic impedance) in 15 anaesthetized normocapnic patients in a stable state after induction of anaesthesia and prior to surgical stimulation. Data showed decrease in mean heart rate (HR) (initial value: 82 beats/min; after 10 min: 57 beats/min; P less than 0.

An analytical pharmacodynamic model for nondepolarizing neuromuscular blocking agents.

A pharmacodynamic model for nondepolarizing neuromuscular blocking agents (NMBA) is developed and tested with different sets of data (NMBA plasma concentration and time evolution of muscular paralysis). This model takes into account the binding of NMBA to the cholinergic motor endplate receptors and thus permits estimation of the apparent equilibrium constant of the NMBA-receptor exchange. The parameters defining the relationship between relative postsynaptic receptor occupation and muscular paralysis can also be determined.

Extra prompts versus no extra prompts in self-care training of autistic children and adolescents.

A color-coded "extra prompt" procedure was compared to a "no extra prompt" procedure in teaching autistic children and adolescents how to lace shoes. One randomly assigned group of 10 autistic subjects first learned to lace shoes whose laces and eyelets were color-coded red and white, and then encountered the no extra prompt condition in which color codes could no longer be depended upon to solve the position discriminations required to lace properly. In a counterbalanced fashion, the other group of 10 autistic subjects reached criterion on the non-color-coded, naturalistic shoe before experiencing the extra prompt condition.