Asparaginase activities during intensified treatment with pegylated asparaginase in adults with newly-diagnosed acute lymphoblastic leukemia.

The GMALL07/2003 protocol introduced pegylated asparaginase (PEG-ASNase) frontline for adults with acute lymphoblastic leukemia (ALL). PEG-ASNase (500 U/m, 1000 U/m, or 2000 U/m) was given once in induction and as part of three HD-MTX/PEG-ASNase cycles with two PEG-ASNase doses every other week in consolidation. PEG-ASNase activities were monitored in 1363 serum samples from 304 ALL patients.