Retinal Vessel Diameter Changes in Relation to Dark Adaptation and Acute Hyperglycemia.

The purpose of this experimental clinical study was to assess the effects of dark adaptation and acute changes in glycemia on retinal vessel diameters in men. The study included 14 patients (mean age 63 years, range 48-74 years) with type 2 diabetes mellitus and minimal or no diabetic retinopathy. Retinal vessel diameters were assessed using infrared photography before and after dark adaptation, first while fasting and then at peak hyperglycemia during an oral glucose tolerance test (OGTT).

Automated refraction is stable 1 week after uncomplicated cataract surgery.

Purpose: To compare automated refraction 1 week and 1 month after uncomplicated cataract surgery.

Methods: In this prospective cohort study, we recruited patients in a 2-month period and included consecutive patients scheduled for bilateral small-incision phacoemulsification cataract surgery. The exclusion criteria were (i) corneal and/or retinal pathology that could lead to automated refraction miscalculation and (ii) surgery complications.

Baseline haemoglobin A1c influences retinal function after long-term insulin pump therapy.

Purpose: The purpose of the study was to characterize the long-term effect of insulin pump therapy (CSII) on electroretinography and dark adaptometry and to examine the influence of baseline glycaemic control on retinal function in patients with type 1 diabetes mellitus.

Methods: This prospective observational extension study enrolled 13 patients out of 17 who completed a primary 1-year study of the effect of CSII on retinal function. Twelve patients were still on CSII at follow-up.

Effect of doxycycline vs placebo on retinal function and diabetic retinopathy progression in patients with severe nonproliferative or non-high-risk proliferative diabetic retinopathy: a randomized clinical trial.

Importance: Inflammation may contribute to the pathogenesis of diabetic retinopathy (DR).

Objectives: To investigate, in a proof-of-concept clinical trial, whether low-dose oral doxycycline monohydrate can (1) slow the deterioration of, or improve, retinal function or (2) induce regression or slow the progression of DR in patients with severe nonproliferative DR (NPDR) or non-high-risk proliferative (PDR), and to determine the potential usefulness of visual function end points to expedite the feasibility of conducting proof-of-concept clinical trials in patients with DR.

Design, Setting, And Participants: We conducted a randomized, double-masked, 24-month proof-of-concept clinical trial.

Cone pathway function in relation to asymmetric carotid artery stenosis: correlation to blood pressure.

Purpose: To examine retinal function in relation to retinal perfusion pressure in patients with carotid artery stenosis.

Methods: Thirteen patients with carotid artery stenosis without clinical eye disease underwent assessment of ophthalmic artery systolic blood pressure (OSP) by ocular pneumoplethysmography, carotid artery obstructive disease by ultrasonography, intraocular pressure by applanation tonometry, retinal perfusion by fluorescein angiography and retinal function by multifocal electroretinography (mfERG). Data analysis compared the eye on the most stenotic side with the fellow eye in the same patient.

Retinal function in relation to improved glycaemic control in type 1 diabetes.

Aims/hypothesis: To study long-term changes in retinal function in response to sustained glycaemia reduction in participants with type 1 diabetes.

Methods: Prospective study using objective measures of retinal function in 17 participants with type 1 diabetes mellitus and minimal to moderate retinopathy who switched from conventional subcutaneous injection to continuous subcutaneous infusion of insulin (CSII).

Results: Glycated haemoglobin HbA(1c) gradually decreased from 9.

Dark adaptation during transient hyperglycemia in type 2 diabetes.

It was the purpose of the present study to examine dark adaptation in subjects with type 2 diabetes during transient hyperglycemia. Twenty-four subjects with type 2 diabetes and minimal diabetic retinopathy were randomized to undergo an oral glucose tolerance test (OGTT) or to remain fasting. Dark adaptometry was measured in one eye, chosen at random, using a computer-controlled dark adaptometer.

Evaluation of macular structure and function by OCT and electrophysiology in patients with vitelliform macular dystrophy due to mutations in BEST1.

Purpose: To analyze retinal structure and function in vitelliform macular dystrophy (VMD) due to mutations in BEST1.

Methods: Patients from five Swedish and four Danish families were examined with electrooculography (EOG), full-field electroretinography (ffERG), multifocal ERG (mfERG), optical coherence tomography (OCT), and fundus autofluorescence photography (FAF). Genetic analysis of the BEST1 gene was performed by direct sequencing.

Scotopic electrophysiology of the retina during transient hyperglycemia in type 2 diabetes.

Purpose: To examine dark-adapted retinal function in subjects with type 2 diabetes during transient hyperglycemia.

Methods: Twenty-four subjects with type 2 diabetes and minimal diabetic retinopathy were randomized to an oral glucose tolerance test (OGTT) or a fasting regimen. One study eye was kept in the dark-adapted state at all times.

Prolonged multifocal electroretinographic implicit times in the ocular ischemic syndrome.

Purpose. To examine retinal function in chronic ocular ischemia using multifocal electroretinography (mfERG). Methods.

CNS metastasis from malignant uveal melanoma: a clinical and histopathological characterisation.

Aim: To characterise uveal melanoma that has metastasised to the central nervous system (CNS).

Methods: Review of 2365 patients constituting all patients diagnosed as having primary uveal melanoma in Denmark during the period 1943-1997. All patients with malignant uveal melanoma and metastasis to the CNS were identified.