MISSION ABC: transforming respiratory care through one-stop multidisciplinary clinics - an observational study.

Objectives: The Modern Innovative Solutions to Improve Outcomes in Asthma, Breathlessness and Chronic Obstructive Pulmonary Disease (COPD) (MABC) service aimed to enhance disease management for chronic respiratory conditions through specialist multidisciplinary clinics, predominantly in the community. This study assesses the outcomes of these clinics.

Design: This study used a prospective, longitudinal, participatory action research approach.

Structural Analysis of the Complex of Human Transthyretin with 3',5'-Dichlorophenylanthranilic Acid at 1.5 Å Resolution.

Human transthyretin (hTTR) can form amyloid deposits that accumulate in nerves and organs, disrupting cellular function. Molecules such as tafamidis that bind to and stabilize the TTR tetramer can reduce such amyloid formation. Here, we studied the interaction of VCP-6 (2-((3,5-dichlorophenyl)amino)benzoic acid) with hTTR.

Outcome of primary internal fixation of (type C) distal humerus fractures in the elderly.

The aim of this review is to evaluate the functional results of open reduction and internal fixation of AO type C distal humerus fractures in elderly patients. Twenty patients were recruited in this study with an average age of 73.5 years.

Primary obturator pyomyositis: a diagnostic challenge.

Pyomyositis of the obturator muscles is a rare condition, characterised by pain in the hip and features of systemic infection. It may follow minor trauma to the hip, sometimes in the presence of an apparently innocuous infective source. All previously reported cases have been diagnosed conclusively on the initial CT or MR scan.

Early femoral loosening in one design of cemented hip replacement.

We have studied aseptic loosening of the femoral component in 76 patients with primary total hip replacement using the Capital prosthesis. The mean follow-up was 26 months (10 to 37). Twelve femoral components (16%) were definitely and eight (10%) were possibly loose.

Excision or Silastic replacement for comminuted radial head fractures. A long-term follow-up.

This report comprises a follow-up of 39 patients after simple excision and 16 patients after Silastic replacement of the radial head for displaced comminuted fractures. Prostheses were used when similar fractures were associated with an unstable elbow. The excision group was followed up for 6.

Fractures of the adult distal humerus. Elbow function after internal fixation.

We reviewed 57 adult patients at an average of 37 months after early internal fixation for displaced fractures of the distal humerus. Two-thirds had intercondylar (Müller type C) fractures, and one-third had articular comminution (type C3). A chevron olecranon osteotomy was used, with early active movement after fixation.

Fracture dislocation of the trapezio-scaphoid joint--the missing link?

Fracture-dislocation of the trapezio-scaphoid joint is an extremely rare injury. We report a case treated using Herbert's compression screw technique.

Fractures of the radial head--the benefit of aspiration: a prospective controlled trial.

The clinical progress of 80 adults with fractures of the radial head was followed prospectively. Early active movement of the elbow and forearm was encouraged in all patients. Better functional results were achieved by the study group than by retrospective controls in whom active movement was delayed.

Nerve tumours in the upper limb. A clinical review.

Tumours arising from the peripheral nerves in the upper limb are rare. This paper reviews eighteen such cases and the clinical outcome. Problems of pre-operative diagnosis are emphasized.

Methods of fixation of olecranon fractures. An experimental mechanical study.

This study was designed to compare the rigidity of the more commonly used techniques of internal fixation of fractures of the olecranon. Cadaveric elbow joints were mounted in a jig and controlled osteotomies performed to simulate transverse, oblique or comminuted fractures. Five techniques of internal fixation were tested by measuring movement at the fracture site after applying a bending moment to the ulna.

Elbow function following tension band fixation of displaced fractures of the olecranon.

Fifty-two patients were reviewed following displaced fractures of the olecranon fixed by the tension band technique. Symptoms, range of movement and strength in flexion and extension were assessed, together with the accuracy of reduction. Eighty-five per cent of patients regained very good function.