Combined effects of artificial dermis and vascular endothelial growth factor concentration gradient on wound healing in diabetic porcine model.

Wounds in patients with diabetes mellitus are one of the most prevalent impaired wounds in the world. Vascular endothelial growth factor (VEGF) is one of the most important proangiogenic mediators. Artificial dermal (AD) such as Pelnac has been shown, in humans and animal models, a great therapeutic potential in full-thickness skin wounds.