Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy.

Almost 5 decades after the first clinical transplantations, delayed immune reconstitution remains a considerable hurdle in bone marrow transplantation, and the mechanisms regulating immune reconstitution after transplantation remain to be established. Whereas adult fms-like tyrosine kinase 3 ligand-deficient (FL(-/-)) mice have reduced numbers of early B- and T-cell progenitors, they sustain close to normal levels of mature B and T cells. Herein, we demonstrate that adult bone marrow cells fail to reconstitute B-cell progenitors and conventional B cells in lethally irradiated FL(-/-) recipients, which also display delayed kinetics of T-cell reconstitution.

Occupational low back pain among workers in some small-sized factories in Ardabil, Iran.

The main purpose of this study was to assess some of the individual and occupational risk factors contributing to induction or intensification of LBP among the employees suffering from this problem in four small size factories in Ardabil, Iran. This study was a cross-sectional study that was conducted among the personnel of four industrial companies. Interview, questionnaire survey, medical examination (Lasegue test), radiographic evaluation, and ergonomic survey (using the NIOSH checklist) were the methods to collect data.