Publications by authors named "Hojjat-Allah Abbaszadeh"
The combining of therapeutic agents with electrospun nanofibers boosts their regeneration potential; therefore, Researchers have increasingly turned towards the development of electrospun nanofiber scaffolds to encapsulate or surface-adsorb biological payloads, such as cytokines, exosomes, peptides, nucleic acids, and enzymes. Due to their high surface-to-volume ratio, ease of manufacturing, and drug-loading capacity, electrospun nanofibers are hopeful in tissue engineering and scaffold fabrication. Electrospun multilayer scaffolds offer a promising construction for preserving the integrity and bioactivity of therapeutic factors while permitting the controlled and prolonged release of biomolecules into the environment.
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- The study investigates how photobiomodulation (PBM) affects the testis of prepubertal male mice exposed to heat stress, which is known to damage testicular health.
- Twenty-four male mice were divided into three groups: a control group, a hyperthermia group, and a hyperthermia plus PBM group, where heat was applied to induce stress and laser therapy was used to assess its protective effects.
- Results showed that the PBM treatment improved sperm quality, increased testicular cell counts, boosted testosterone levels, and reduced harmful oxidative stress, suggesting that laser therapy can help protect the testis from heat damage during critical developmental periods.
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- Unhealthy lifestyle choices like alcohol, chemicals, and heat stress can negatively impact male fertility by damaging the blood-testis barrier (BTB), which is crucial for sperm production.
- Recent studies have explored photobiomodulation therapy (PBMT) as a way to improve sperm quality, particularly in cases with genital inflammation.
- In an experiment with male mice subjected to heat stress, PBMT was found to significantly enhance sperm quality and the health of the BTB, offering a promising method for treating male infertility.
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- Huntington's disease is a genetic disorder characterized by the progressive degeneration of brain nerve cells, leading to motor and cognitive issues, with no definitive cure available yet.
- A study tested the drug Apelin-13 on male Wistar rats with a Huntington’s disease model to see if it could help improve symptoms and reduce inflammation.
- Results showed that Apelin-13 treatment enhanced motor function, increased neuronal density, reduced inflammation, and improved overall brain health in the rats.
Exosome Therapy and Photobiomodulation Therapy Regulate mi-RNA 21, 155 Expressions, Nucleus Acetylation and Glutathione in a Polycystic Ovary Oocyte: An In Vitro Study.
Samira Sahraeian Hojjat Allah Abbaszadeh Robabeh Taheripanah Mohammad Amin Edalatmanesh Somayeh Keshavarzi
J Lasers Med Sci
April 2024
Article Synopsis
- - PCOS is a complicated condition that can lead to infertility, with miRNA regulation linked to its development.
- - This study tested the effects of photobiomodulation therapy (PBMT) and exosome therapy (EXO) on oocytes from PCOS patients by dividing them into control, EXO, and PBMT groups and running various tests.
- - Results indicated that both therapies improved key cellular factors like glutathione levels and nucleus acetylation, while also altering miRNA expression compared to the control group.
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- - The study focuses on diabetic foot ulcers (DFUs), highlighting their serious complications and the need for a multidisciplinary treatment approach that covers their causes and various treatment options available.
- - An extensive literature review (2000-2023) examines treatments like wound dressings, photobiomodulation therapy, off-loading devices, and stem cell therapy, all aimed at enhancing healing in DFUs.
- - Given the complexity of DFU pathophysiology, successful treatment relies on a combination of methods, including maintaining a moist environment, reducing ulcer pressure, and utilizing advanced therapies to boost tissue regeneration.
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- Despite advancements in wound dressings, delayed wound closure remains a global issue, highlighting the need for innovative solutions and tissue engineering.
- A new wound dressing using carboxylated cellulose combined with pal-KTTKS was developed to enhance collagen synthesis, cell adhesion, and biocompatibility while promoting faster wound healing.
- In studies with male rats, the MSC-KTTKS-CBC composite demonstrated significantly improved healing outcomes, outperforming other treatments in reducing inflammation and accelerating wound closure.
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- Scrotal hyperthermia negatively affects sperm production and male fertility, prompting this study to explore the impact of vitamins B12 and C in adult male mice exposed to prolonged heat.
- After 35 days of vitamin treatment, vitamin C showed greater improvements in sperm quality and reduced cell death compared to vitamin B12, alongside beneficial changes in oxidative stress markers.
- The study concludes that vitamins B12 and C may offer therapeutic benefits for male reproductive health under heat stress, suggesting vitamin supplementation as a viable strategy to combat fertility issues linked to increased scrotal temperatures.
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- Acute kidney injury (AKI) is a serious health issue that can lead to significant complications and death, making the search for effective treatments essential.
- Renal Progenitor Cells (RPCs), particularly those derived from human embryonic stem cells, show promise in treating AKI by improving kidney function and structure.
- Research findings indicate that these RPCs can successfully repair damaged kidneys in mice, reducing symptoms like inflammation and kidney damage, suggesting potential for future therapies.
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- The study investigated the effects of exosome therapy (EXO) and photobiomodulation therapy (PBMT) on infertility in male mice caused by scrotal hyperthermia, which damages sperm due to high temperatures.
- Mice were divided into four groups: a control group, a hyperthermia group, and two treatment groups receiving EXO or PBMT for 30 days after hyperthermia exposure.
- Results showed significant improvements in sperm parameters, testicular tissue volume, germ, Leydig, and Sertoli cell counts, as well as testosterone levels in treated groups, alongside reduced oxidative stress indicators compared to the hyperthermia group.
Neuroprotective effect of human cord blood-derived extracellular vesicles by improved neuromuscular function and reduced gliosis in a rat model of Huntington's disease.
Reza Bahar Shahram Darabi Mohsen Norouzian Susan Roustaei Shayesteh Torkamani-Dordshaikh Hojjat-Allah Abbaszadeh
J Chem Neuroanat
July 2024
Huntington's disease (HD) is a hereditary condition characterized by the gradual deterioration of nerve cells in the striatum. Recent scientific investigations have revealed the promising potential of Extracellular vesicles (EVs) as a therapy to mitigate inflammation and enhance motor function. This study aimed to examine the impact of administering EVs derived from human umbilical cord blood (HUCB) on the motor abilities and inflammation levels in a rat model of HD.
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- Regenerative medicine techniques are being explored for treating osteoarthritis (OA), focusing on the regeneration of both chondral and subchondral tissues simultaneously.
- A biphasic scaffold was created using chitosan, hyaluronan, alginate, and nano-hydroxyapatite, which demonstrated strong mechanical properties and confirmed porosity via scanning electron microscopy.
- The study found that this scaffold promoted the growth of specific bone and cartilage cells, indicating its potential as a new implant strategy for OA treatment.
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- An increase in testicular temperature can harm sperm production and the structure of seminiferous tubules, prompting this study on the effects of Sertoli cell-conditioned medium (SCCM) in mice.
- The experimental study involved four groups of adult NMRI mice subjected to various treatments, including scrotal hyperthermia, to evaluate the impact on sperm parameters and testicular health.
- Results showed SCCM treatment improved sperm count, motility, and reduced DNA fragmentation, while also enhancing testicular tissue volume and the expression of specific genes related to spermatogenesis and the blood-testis barrier.
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- * LDX-treated rats showed impaired memory performance in various tests and exhibited changes in brain activity, with an increase in field excitatory postsynaptic potential and elevated caspase-3 levels, indicating potential cell death.
- * The study found significant increases in immune cells (microglia and astrocytes) in the hippocampus, along with changes in cell structure, pointing to harmful effects of LDX on this vital area of the brain related to memory; more research is required to fully understand
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- Biophoton emission refers to the spontaneous release of light from living cells, which recent research suggests could indicate disease states by signaling changes in cell communication and interaction.
- A study involving male mice revealed that those treated with busulfan, a drug causing oligospermia (low sperm count), displayed higher levels of biophoton emission compared to the control group, signifying altered intercellular dynamics.
- Findings indicated that the busulfan treatment led to a significant reduction in testis volume and cell numbers, alongside increased cell death, suggesting that decreased biophoton emission may reflect structural and functional disruptions in cells.
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- Concerns about lisdexamfetamine (LDX), a drug for ADHD, include potential irreversible brain damage and impacts on the neuroendocrine system during development.
- A study on adult male rats found that LDX treatment resulted in decreased sperm motility, increased DNA fragmentation, and significantly lower testosterone levels.
- The study suggests prolonged LDX use may lead to poor sperm quality and harmful changes in testicular tissue, but further research is needed, especially in humans using LDX long-term.
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- * Chronic use of METH disrupts the normal function of neurotransmitters like dopamine, leading to various stress responses and cell death processes in the brain.
- * The article reviews the detrimental effects of METH on neuronal activities and discusses the need for new treatment strategies to combat its neurotoxic impact.
Article Synopsis
- - The mammalian kidney, particularly its nephrons (the filtering units), is complex, and adult kidneys struggle to regenerate new nephrons due to a lack of renal progenitor cells (RPCs) as they age.
- - Recent advances in regenerative medicine have highlighted important signaling pathways that can help maintain and generate RPCs, especially from pluripotent stem cells.
- - This research focuses on identifying key transcription factors and signaling pathways related to RPCs, aiming to improve strategies for kidney protection and develop new treatments.
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- - Diabetes can cause serious complications like diabetic foot ulcers (DFUs), which can lead to infections and amputations, highlighting the need for better treatments.
- - The study explored the effectiveness of photobiomodulation therapy (PBT) and autologous platelet gel (APG) on healing DFUs, analyzing data from various reputable medical databases and selecting 57 relevant studies.
- - Results indicated that both APG and PBT can significantly improve healing times, reduce pain, and decrease the need for surgeries, marking them as promising treatments for managing DFUs.
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- - Methamphetamine (METH) disrupts neurotransmitter activity in the central nervous system, leading to neurotoxicity through various pathways, including increased reactive nitrogen and oxygen species and mitochondrial apoptosis.
- - This study analyzed structural changes in the amygdala of ten male postmortem brains, comparing chronic METH users to control subjects using various scientific techniques like immunohistochemistry and real-time PCR.
- - Results showed METH addiction led to decreased levels of protective proteins and increased inflammation and neurodegeneration in the amygdala, with reactive oxygen species production linked to specific signaling pathways.
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- * This systematic review and meta-analysis evaluated various biomarkers to understand their connection to SSNHL prognosis, with a focus on studies up to October 2022.
- * Findings indicated that a higher neutrophil to lymphocyte ratio (NLR) correlates with poorer outcomes, while the platelet to lymphocyte ratio (PLR) and other biomarkers like blood glucose and serum endocan have mixed results; overall, PLR, NLR, and neutrophil counts are useful for predicting recovery in SSNHL patients.
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- Chronic damage to kidneys can lead to renal fibrosis, characterized by inflammatory processes and excessive extracellular matrix production, prompting this study to investigate the effects of extracellular vesicles from adipose-derived stem cells on kidney inflammation and fibrosis.
- Autophagy in these stem cells was triggered using curcumin, and the study involved developing a renal fibrotic model using HEK-293 cells exposed to H2O2, with various gene expressions evaluated post-treatment with different types of extracellular vesicles.
- Results indicated that vesicles from autophagy-induced cells (AEVs) significantly improved anti-fibrotic and anti-inflammatory responses compared to non-autophagy vesicles (NEVs), suggesting AEVs may be a promising treatment for renal fibrosis
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- - Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women that often leads to infertility due to ovulation issues, and its exact cause remains unclear.
- - This study investigates the effects of extracellular vesicles (ECV) from cord blood plasma and photobiomodulation therapy (PBMT) on oocyte maturation in women with PCOS undergoing infertility treatment.
- - Results showed that both ECV and PBMT significantly improved the maturation and fertilization rates of oocytes, reduced apoptosis and autophagy, and altered various gene expressions related to these processes.
Acetyl-11-Keto-Beta-Boswellic Acid Has Therapeutic Benefits for NAFLD Rat Models That Were Given a High Fructose Diet by Ameliorating Hepatic Inflammation and Lipid Metabolism.
Reza Ataei Kachouei Alireza Doagoo Maral Jalilzadeh Seyyed Hossein Khatami Shima Rajaei Hojjat Allah Abbaszadeh
Inflammation
October 2023
Article Synopsis
- Acetyl-11-keto-beta-boswellic acid (AKBA) is an anti-inflammatory compound studied for its effectiveness in preventing and treating non-alcoholic fatty liver disease (NAFLD) in male Wistar rats.
- The study included groups treated with AKBA either during a high fructose diet for 6 weeks or after switching to a normal diet for 2 weeks, analyzing various liver-related parameters and inflammatory markers.
- Results indicated that AKBA improved liver health indicators and inflammation, supported lipid metabolism, and helped maintain crucial proteins that regulate cellular energy, suggesting it could be a potential treatment for NAFLD.
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- Testicular heat stress negatively affects sperm production in mammals, but the exact mechanisms are not fully understood; researchers are exploring ways to reverse this damage caused by high temperatures.
- The study investigated the effects of photobiomodulation therapy (PBMT) on sperm development in mouse models that experienced heat-induced sperm failure (azoospermia).
- Results showed that PBMT with lower intensity (0.03 J/cm) improved sperm production by increasing cell activity and reducing harmful substances, ultimately restoring spermatogenesis in the affected mice.