A functional SNP in miR-146a and genetic susceptibility to drug-resistant epilepsy.

Objectives: The study aimed to assess the relationship between the functional single nucleotide polymorphism (SNP) (rs57095329) of miR-146a, the progression of drug-resistant epilepsy (DRE), and the severity of the disease (seizure frequency) in a group of Egyptian children epilepsy patients.

Subjects And Methods: 110 Egyptian children were recruited and divided into two groups, the epilepsy patients ( = 60) and the healthy control children ( = 50). The patient's group was equally subdivided into two subgroups: drug-resistant and drug-responsive epilepsy patients.

Impaired Pancreatic β-Cell Function in Critically Ill Children.

Critical illness hyperglycemia (CIH) is common in the pediatric intensive care unit (PICU). Increased glucose production, insulin resistance (IR), and pancreatic β-cell dysfunction are responsible mechanisms. We aimed to investigate β-cell function in the PICU and to uncover its relation to clinical and laboratory variables and ICU mortality.

Relation between Baseline Total Serum Cortisol Level and Outcome in Pediatric Intensive Care Unit.

Elevated cortisol level is an component of the stress response. However, some patients have low cortisol levels; a condition termed: critical illness-related corticosteroid insufficiency (CIRCI). Basal cortisol levels during PICU admission may be related to outcome.

Serum complement factor H and Tyr402 His gene polymorphism among Egyptians with multiple sclerosis.

Background And Objectives: Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system. A contribution from complement has long been suspected. We investigated the association of complement factor H (CFH) Tyr402 His gene polymorphism and serum level in Egyptian patients with MS to examine whether complement might identify or predict specific pathological processes and outcomes in MS.

Vascular endothelial growth factor-A mRNA gene expression in clinical phases of multiple sclerosis.

Background: Vascular endothelial growth factor A stimulates angiogenesis, but is also pro-inflammatory and plays an important role in the development of neurological disease. This study aimed to investigate whether vascular endothelial growth factor A mRNA expression could be used as a marker for the prediction of susceptibility to multiple sclerosis and relate vascular endothelial growth factor to the clinical phases of multiple sclerosis.

Methods: This was a cross-sectional study, consisting of a total of 60 subjects with multiple sclerosis and 20 healthy controls.

Prevalence of celiac disease among type 1 diabetic Egyptian patients and the association with autoimmune thyroid disease.

Background: Celiac disease (CD) is a common genetically transmitted immune mediated disease.

Method: Seventy three type 1 DM patients attending the Diabetes, Metabolic and Endocrinology outpatient clinic were recruited in the study. Thorough history taking and medical examination were done.