Publications by authors named "Hoi-Ying Shiu"
Insulin receptor substrate-1 (IRS-1) mediates signaling from the insulin-like growth factor type-I receptor. We found that all-trans retinoic acid (RA) decreases IRS-1 protein levels in MCF-7, T47-D, and ZR75.1 breast cancer cells, which are growth arrested by RA, but not in the RA-resistant MDA-MB-231 and MDA-MB-468 cells.
View Article and Find Full Text PDFRetinoic acid (RA) overcomes the maturation block in t(15:17) acute promyelocytic leukemia (APL), leading to granulocytic differentiation. Patients receiving RA alone invariably develop RA resistance. RA-resistant cells can serve as useful models for the development of treatments for both APL and other leukemias.
View Article and Find Full Text PDFArticle Synopsis
- Researchers created a bicistronic retroviral vector called MFG/GID that expresses two specific proteins, enhancing resistance to chemotherapy drugs chlorambucil and trimetrexate (TMTX) in a mouse cell line.
- When murine fibroblasts were treated with this vector, they showed a significant increase in their ability to survive these drugs, with some cells maintaining almost complete survival under high concentrations of TMTX.
- The study suggests that using this vector to select for genetically modified hematopoietic cells could improve their resistance to certain chemotherapeutics, potentially increasing the effectiveness of treatments during or after cell transplantation.