Publications by authors named "Hoi-Yee Li"
Objectives: Sarcopenia is recognized to be a health problem which is as serious as obesity, but its relevance to mortality is unclear. We conducted a meta-analysis of cohort studies on lean mass and mortality in populations with different health conditions.
Methods: In this study, a systematic search of PubMed, Cochrane Library and Embase was performed for cohort studies published before Dec 20, 2017 which examined the relationship between lean mass and mortality.
Article Synopsis
- The study investigates thyrotoxic periodic paralysis (TPP), a serious complication of hyperthyroidism, by analyzing genetic data from 319 TPP patients and 3,516 healthy individuals to identify potential genetic risk factors.
- Through the analysis of over 7 million genetic variants, researchers found 260 significant variants linked to TPP, including two novel risk loci near the TRIM2 and AC140912.1 genes, which were associated with changes in gene expression.
- The findings suggest that common genetic variations may play a role in TPP, potentially leading to milder symptoms compared to rare mutations previously associated with more severe muscle paralysis disorders.
Aim: To study the molecular mechanism of laterally spreading tumor (LST), a cell line [Laterally Spreading Tumor-Rectum 1 (LST-R1)] was derived and the characteristics of this cell line were investigated.
Methods: A new cell line (LST-R1) originated from laterally spreading tumor was established. Properties of the cell line were characterized using scanning and transmission electron microscopy, immunohistochemistry method, cytogenetic analysis and nude mice xenograft experiments.
Recently, a series of gold(III) meso-tetraarylporphyrins that are stable against demetallation in physiological conditions have been synthesized. In the present study, the antitumor effects of one of these compounds, gold(III) meso-tetraarylporphyrin 1a (gold-1a) was investigated in an orthotopic rat hepatocellular carcinoma (HCC) model as well as using a HCC cell line. The rat HCC model was induced by injection of rat hepatoma cells, McA-RH7777, into the left lobe of the liver.
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