Publications by authors named "Hoi Ching Lee"
Aim: Sex differences are well documented in schizophrenia, but have been much less studied in at-risk mental state (ARMS) for psychosis. We aimed to examine sex differences in symptomatology, cognition, social and role functioning in individuals with ARMS, with specific focus on clarifying relationships between sex, negative symptoms and functioning.
Methods: One hundred and seventy-seven Chinese participants aged 15-40 years with ARMS were recruited from a specialized early intervention service in Hong Kong.
Aim: Psychiatric comorbidity frequently occurs with at-risk mental state (ARMS) for psychosis. Its relationships with psychopathology, cognition and functioning, however, remain to be further clarified. We aimed to examine prevalence and correlates of psychiatric comorbidity, and its associations with psychosocial functioning and subjective quality-of-life (QoL) in a representative sample of Chinese ARMS individuals.
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- The hexanucleotide repeat expansion in the C9ORF72 gene is the leading cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but its functional impact and disease mechanism are still unclear.
- Research using a mouse model lacking C9orf72 revealed immune system alterations, such as increased myeloid cells, activated T cells, and elevated autoantibodies.
- The findings suggest that C9orf72 is important for maintaining immune balance and may indicate that deficiency in this gene isn't the main cause of ALS/FTD pathology.