Similar adverse outcome rates with high or low oxygen saturation targets in an area with low background mortality.

Background: Randomized controlled trials have indicated reduced mortality rates in very preterm infants assigned to high compared to low oxygen saturation (SpO) target levels, accompanied by higher rates of retinopathy of prematurity and bronchopulmonary dysplasia. However, the benefit-to-harm ratio may depend on the local background mortality risk. We therefore aimed to quantify the risk-benefit ratios of different SpO target ranges in 10 tertiary newborn intensive care units (NICUs) in East Germany.

Bladder cancer course, four genetic high-risk variants, and histopathological findings.

Urinary bladder cancer, a smoking and occupation related disease, was subject of several genome-wide association studies (GWAS). However, studies on the course of the disease based on GWAS findings differentiating between muscle invasive bladder cancer (MIBC) and non-muscle invasive bladder cancer (NMIBC) are rare. Thus we investigated 4 single nucleotide polymorphisms (SNPs) detected in GWAS, related to the genes coding for TACC3 (transforming, acidic coiled-coil containing protein 3), for FGFR3 (fibroblast growth factor receptor 3), for PSCA (prostate stem cell antigen) and the genes coding for CBX6 (chromobox homolog 6) and APOBEC3A (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A).

Impact of the COVID-19 Pandemic Regulations on the Health Status and Medical Care of Children with Trisomy 21.

Background: While children are considered at low risk for COVID-19, little is known about the impact of SARS-CoV-2 on paediatric risk patients like children with Trisomy 21 (T21). As these children often need regular therapy and various medical appointments, this study aimed to investigate the possible impact of the COVID-19 pandemic on children with T21.

Patients And Methods: Parents of children with T21 in the age of 0-12 years in Saxony-Anhalt were interviewed via phone in June 2021 regarding the health status and medical care of their children during the past 15 months of pandemic.

Visualization of Medical Wearable-Data Using SMART-on-FHIR - A Concept for an Interdisciplinary Complex Practical Course.

For the success of digital applications, especially AI applications, it is essential that both developers and medical professionals are enabled to understand each other's perspective. For this reason, a new concept for an interdisciplinary complex practical course was developed for the master's program in computer science at a German university, based on online learning nuggets and a hackathon on site. The core of the concept is a real-world medical application task: extracting ECG patient data from a smartwatch to support primary care physicians in making decisions regarding an action.

A New Measuring System for the Determination of the Ice Adhesion Strength on Smooth Surfaces.

To gain knowledge about cause-effect relationships for the adhesion of ice on surfaces with different chemical groups, we wanted to study the effect of thin polymer layers on the ice adhesion strength. To minimize the effect of roughness, smooth substrates that have generally relatively low ice adhesion strengths were chosen. To be able to obtain highly reproducible values for the region of low ice adhesion and to measure small differences of ice adhesion at surfaces with different chemical compositions, a new measuring system for the determination of the ice adhesion strength which is based on a modified spin-coater was developed.

The Esophageal Manometry with Gas-perfused Catheters.

Background: The well-established methods for esophageal manometry have some disadvantages: the-water-perfused catheters needs calibration by gravity and measuring in supine position, and the solid-state catheters are very expensive. Manometry using gas-perfused catheters is a suitable alternative. There have been only a few publications about this.

Standard values for gas-perfusion manometry of the esophagus.

The manometry with water-perfused or solid-state catheters is the predominant diagnostic procedure to detect motility disorders of the esophagus. Another method is the manometry using gas-perfused catheters. Although the high-resolution manometry is the method of first choice, the conventional manometry with helium has some advantages: the simple and hygienically unproblematic use and the absence of any artefacts by the perfusion medium compared with water-perfusion, and the considerably lower costs compared with the solid-state catheters.

N-acetyltransferase 1*10 genotype in bladder cancer patients.

In a large bladder cancer study in the greater Berlin area with 425 cases and 343 controls, the haplotype N-acetyltransferase 1*10 (NAT1*10) was associated with a decreased bladder cancer risk. In a recently published meta-analysis, results of the studies were found to be inconclusive. Therefore, the aim of this study was to investigate the frequency of NAT1*10 in bladder cancer patients and controls recruited in an area without industries reported to be associated with increased bladder cancer risk.

Patella Dislocation in Children and Adolescents.

Patellar dislocation is one of the commonest knee injuries in adolescents. Although treatment usually leads to good results, the influence of anatomical and functional factors on therapeutic strategy has been underestimated, especially in cases of recurrence. The course of treatment has been analysed in 88 patients with 136 patellar dislocations.

Inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT): a representative literature review occasioned by a rare IMT of the transverse colon in a 9-year-old child.

Aims And Background: Inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT) represent different entities. However, it is only in recent years that this has been taken into increasing consideration. Some authors still use both terms synonymously or interchangeably.

Tunable Hydrophilic or Amphiphilic Coatings: A "Reactive Layer Stack" Approach.

Thin films with tunable properties are very interesting for potential applications as functional coatings with, for example, anti-icing or improved easy-to-clean properties. A novel "reactive layer stack" approach was developed to create covalently grafted mono- and multilayers of poly(glycidyl methacrylate)/poly(tert-butyl acrylate) diblock copolymers. Because these copolymers contain poly(glycidyl methacrylate) blocks they behave as self-cross-linking materials after creation of acrylic acid functionalities by splitting off the tert-butyl units.

[Function of oesophagus and gastro-oesophageal reflux in patients with cystic fibrosis].

Gastro-oesophageal reflux (GER) has a special meaning for patients with cystic fibrosis (CF). Twelve voluntary patients with CF up to the age of 25 underwent an oesophageal manometry and a 24-hour impedance-pH monitoring. These patients were without symptoms of GER.

Ovarian borderline tumors in pre-menarche girls.

By reason of a new case of an ovarian mucinous borderline tumor (BOT) in a pre-menarche girl, a research of current literature was implemented. Low-grade malignant epithelial tumors are extremely rare in young children and, as far as we know, only a few case reports exist. The patients presented with vomiting, pain, and a swollen lower abdomen.

Adsorption of poly(vinylformamide-co-vinylamine) polymers (PVFA-co-PVAm) on copper.

The adsorption of poly(vinylformamide) (PVFA) and its derivative statistical copolymer poly(vinyl-formamide-co-vinylamine) (PVFA-co-PVAm) on metallic copper and copper oxide particles as well as planar copper surfaces was studied as a function of the degree of hydrolysis of PVFA, the pH, and the polymer concentration in solution. The chemical composition and molecular structure of the PVFA-co-PVAm layers were investigated by surface-sensitive spectroscopic methods such as XPS, DRIFT spectroscopy, and ellipsometry. The findings allowed us to explain the adsorption mechanisms and the forces driving the PVFA-co-PVAm adsorption.

Evidence of thromboembolism prophylaxis in bariatric surgery-results of a quality assurance trial in bariatric surgery in Germany from 2005 to 2007 and review of the literature.

Background: Since January 1st, 2005, the current situation for bariatric surgery has been examined by means of a voluntary quality assurance study in Germany with a multicenter design in which 38 hospitals and surgical departments participated. The data are registered in cooperation with the Institute of Quality Assurance in Surgery at the Otto-von-Guericke University of Magdeburg (Germany).

Methods: Data describing peri-interventional characteristics were prospectively documented in an internet online data registry.

Results of sleeve gastrectomy-data from a nationwide survey on bariatric surgery in Germany.

Background: Beginning January 1, 2005, the status and outcomes of bariatric surgery were examined in Germany. Data are registered in cooperation with the An-Institute of quality assurance in surgery at the Otto-von-Guericke-University Magdeburg. The objective of this study was to examine the morbidity and mortality rates secondary to sleeve gastrectomy (SG) in Germany since 2006.

Status of bariatric surgery in Germany--results of the nationwide survey on bariatric surgery 2005-2007.

Background: Most studies on bariatric surgery outcomes are performed as clinical trials or reflect the clinical experience in single centers. The status of bariatric surgery in Germany has been examined with the cooperation of clinics and hospitals at the Institute of Quality Assurance in Surgery at the Ottovon-Guericke University of Magdeburg (Germany) since January 1, 2005.

Methods: In this prospective multicenter observational study, the data obtained for all primary bariatric procedures, including all repeated operations, performed on consecutive patients with morbid obesity at participating hospitals from 2005 to 2007 were prospectively collected using an internet online data registry.

A nationwide survey on bariatric surgery in Germany--results 2005-2007.

Background: Most studies on bariatric surgery outcomes are performed as clinical trials or reflect the clinical experience in single centers. The status of bariatric surgery in Germany has been examined since January 1st, 2005 with the cooperation of clinics and hospitals at the Institute of Quality Assurance in Surgery at the Otto-von-Guericke University of Magdeburg (Germany).

Methods: In this prospective multicenter observational study, the data obtained for all primary bariatric procedures, including all repeated operations, performed on consecutive patients with morbid obesity at participating hospitals from 2005 to 2007 were prospectively collected using an Internet online data registry.

[Quality assurance in bariatric surgery in Germany--results of the German multicentre trial 2005 and 2006].

Background: Since January 1st 2005, the situation of bariatric surgery in Germany has been examined. The data are registered in cooperation with the Institute of Quality Assurance in Surgery at the Otto-von-Guericke-University Magdeburg.

Methods: The data registration took place prospectively in an internet online data base.

Experiences of two centers of bariatric surgery in the treatment of intragastrale band migration after gastric banding-the importance of the German multicenter observational study for quality assurance in obesity surgery 2005 and 2006.

Background: Adjustable silicone gastric banding (ASGB) is an effective treatment in morbid obesity. Band migration is a long-term complication. Causes, clinical symptoms, timing and incidence are investigated in single centres only.

Hydrophobic chitosan microparticles: heterogeneous phase reaction of chitosan with hydrophobic carbonyl reagents.

Hydrophobically modified chitosan microparticles were produced by various syntheses carried out as heterogeneous phase reactions. Perfluorinated carbonyl components such as carbonic acids and acid chlorides were used as hydrophobization agents. To enhance the layer stability preceding cross-linkages between the chitosan macromolecules were introduced.

Intramural bladder-wall abscess: a late complication arising after a urethrocystoscopy?

Intramural bladder-wall abscesses are serious but rather rare. In the few reported cases, their aetiology has not been explicitly explained. In our case, we found a traumatic outcome induced by a urethrocystoscopy that had taken place 4 years prior to the diagnosis of abscess.

Computer-assisted learning in human and dental medicine.

This article describes the development and application of new didactic methods for use in computer-assisted teaching and learning systems for training doctors and dentists. Taking the Meducase project as an example, didactic models and their technological implementation are explained, together with the limitations of imparting knowledge with the "new media". In addition, legal concepts for a progressive, pragmatic, and innovative distribution of knowledge to undergraduate students are presented.

Effects of altered gravity on the swimming behaviour of fish.

Humans taking part in parabolic aircraft flights (PAFs) may suffer from space motion sickness-phenomena (SMS, a kinetosis). It has been argued that SMS during PAFs might not be based on microgravity alone but rather on changing accelerations from 0 g to 2 g. We test here the hypothesis that PAF-induced kinetosis is based on asymmetric statoliths (i.