[Clinical aspects of vaginal hysterectomy].

From 1971-1982 4,179 hysterectomies have been performed by vaginal route on the department of gynecology and obstetrics of the Klinikum Mannheim. 46.5% of these women were between 20 and 40 years old, 7.

[Conization of the uterine cervix. A study of 900 cases].

In the years 1968 till 1982, 900 conisations of uterine cervix were performed, 90% of which were diagnostic interventions. During the follow-up period, the mean age of the patients with carcinoma in situ decreased 4 years, the mean age from patients with microcarcinoma 3.2 years.

[Cesarean section with subsequent hysterectomy].

We had 65 Caesarean hysterectomies from 1960-1982 at our hospital. 43 patients were elected for various reasons: contraception 26, fibromatosis 13, intraepithelial neoplasia 4. 22 had vital indications: rupture of the uterus 12, placenta increta/percreta 5, abruptio placentae 3, atony 2.

Carcinoma of the cervix stage T1b. A 15 years review of 256 cases.

256 patients of the years 1965-1979 who suffered from collum carcinoma stage T1b were reviewed. Most of the neoplasmas were squamous cell carcinoma (81%). By tumor screening only 21% of the carcinomas were detected.

[Value of cervix cerclage].

Between 1965 and 1980 we performed 512 Shirodkar operations. Mean age of the patients was 28.4 years.

Intermediate filaments of normal and neoplastic tissues of the female genital tract with emphasis on problems of differential tumor diagnosis.

Cytokeratins of normal epithelia and of some neoplasms of the female genital tract were studied by immunofluorescence microscopy of frozen sections and by two-dimensional gel electrophoresis of cytoskeletal proteins from microdissected tissues. All normal epithelia were stained with the monoclonal cytokeratin antibody KG 8.13 whereas certain monoclonal antibodies stained only simple epithelia.

[Histological reaction of the endometrium to irritation by a probe in relation to the problem of embryo transfer during in-vitro fertilization].

The purpose of this study was to try to explain morphologically why a high percentage of artificially inseminated embryos fail to implant after intrauterine transfer. To investigate the problem we irritated with a probe the endometria of 31 women of child-bearing age a few days before their scheduled hysterectomies. Our histological studies of the uteri were directed towards learning whether a localised decidual change had developed at the site of mechanical irritation.

[Spontaneous rupture of a deciduoma with intra-abdominal hemorrhage].

A so-called Deciduoma caused severe intraabdominal haemorrhage in third trimester of pregnancy. The bleeding from the hypervascular tumor resulted in the decompensation of balanced placental insufficiency and thus led to fetal distress.

[Vaginal hysterectomy with bilateral adnexectomy].

102 bilateral adnexectomies in simple vaginal uterectomy (UE.A.) were researched between 1975-1980 and compared to the same number of patients who had vaginal uterectomy without adnexectomy (VK).

[Hemorrhaging in early pregnancy].

283 patients with vaginal bleedings in the first three months of pregnancy were included in an analysis and compared to a control group. We could not find a correlation between bleeding in the early weeks of pregnancy and the age of the mother, the onset of menarche, parity, and preceded premature deliveries. On the other hand we found a significantly high number of bleedings in women, who already had abortions before, and diseases during pregnancy (infections, hyperemesis gravidarum).

[Hysterectomy in young women].

It is reported upon 1345 hysterectomies on patients up to 35 years of age between 1966 and 1981. Proportionately these young women were 16% of all hysterectomies. 69.

Cytokeratins of normal epithelia and some neoplasms of the female genital tract.

Cytokeratins are a family of polypeptides of intermediate filaments which in diverse epithelia are expressed in different, yet specific, combinations. We have studied the cytokeratins present in normal epithelia of the female genital tract, in comparison with those present in genital tract carcinomas, by two-dimensional gel electrophoresis of cytoskeletal proteins from microdissected tissues and by immunofluorescence microscopy. Cells of ovarian mesothelium, oviduct, endometrium, and endocervix contain cytokeratin polypeptides nos.

[Diagnostic evaluation of drill biopsy].

This report describes the procedure of drill biopsy in 100 patients with palpable breast tumours. In 99% of the biopsies the lesion was accurately diagnosed, in 61% as invasive carcinoma.

[Premature birth. Retrospective study of 2000 premature births at the Gynecological Clinic of the University of Mannheim. 2: Postpartum period, morbidity and mortality of premature infants].

During a period from 1966 to 1977 a retrospective study on 1982 premature births was conducted. 9,4% of the premature births were dead born; from the births, who died in the postnatal period, 94% died within the first 7 days, perinatal mortality was 27%. Most common cause of death was immaturity (25%), followed by respiratory distress syndrome (16%), in 31% cause of death was unknown.

Carcinoma of the vulva.

From 1966 to 1981 96 patients with carcinoma of the vulva received their primary treatment at the Frauenklinik of the Klinikum Mannheim. The average age was 69 years at the time of the diagnosis. Histologically keratinizing squamous cell carcinoma was found in 78.

Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria.

Eleven biphasic uterine tumors with epithelial components and homologous stroma were reevaluated. Originally these were diagnosed as adenofibroma, adenosarcoma, carcinosarcoma, or mixtures thereof, but were now reclassified as adenosarcomas of which seven were "pure" and four mixed with foci of carcinosarcoma. Nine of the tumors arose in the endometrium and two in the endocervix.

[Causes of the antibacterial action of amniotic fluid (author's transl)].

The activity of E. coli, Group B Streptococci, Strept. faecalis, Stap.