Guest-Mediated Modulation of Photophysical Pathways in a Coronene Bisimide Cyclophane.

The properties and functions of chromophores utilized by nature are strongly affected by the environment formed by the protein structure in the cells surrounding them. This concept is transferred here to host-guest complexes with the encapsulated guests acting as an environmental stimulus. A new cyclophane host based on coronene bisimide is presented that can encapsulate a wide variety of planar guest molecules with binding constants up to (4.

Ultrastable Zinc Anode Enabled by CO-Induced Interface Layer.

Aqueous Zn-ion batteries (AZIBs), being safe, inexpensive, and pollution-free, are a promising candidate for future large-scale sustainable energy storage. However, in a conventional AZIBs setup, the Zn metal anode suffers oxidative corrosion, side reactions with electrolytes, disordered dendrite growth during operation, and consequently low efficiency and short lifespan. In this work, we discover that purging CO gas into the electrolyte could address these issues by eliminating dissolved O, inhibiting side reactions by buffering the local pH change, and preventing dendrite growth by inducing the in situ formation of a ZnCO solid electrolyte interphase layer.

Targeting IRAK3 for Degradation to Enhance IL-12 Pro-inflammatory Cytokine Production.

Interleukin-1 receptor-associated kinase 3 (IRAK3) is a pseudokinase mediator in the human inflammatory pathway, and ablation of its function is associated with enhanced antitumor immunity. Traditionally, pseudokinases have eluded "druggability" and have not been considered tractable targets in the pharmaceutical industry. Herein we disclose a CRISPR/Cas9-mediated knockout of IRAK3 in monocyte-derived dendritic cells that results in an increase in IL-12 production upon lipopolysaccharide (LPS) stimulation.

Acceptance of virtual consultations among older adults and caregivers in Malaysia: a pilot study during the COVID-19 pandemic.

Aim: The COVID-19 pandemic has disrupted the delivery of healthcare to vulnerable older adults, prompting the expansion of telemedicine usage. This study surveyed the acceptance of virtual medical consultations among older adults and caregivers within geriatric outpatient services in a tertiary hospital during the pandemic.

Methods: A cross-sectional survey was conducted among caregivers and patients attending geriatric outpatient services in Kuala Lumpur, Malaysia.

The impact of vitrectomy on outcomes achieved with 0.19 mg fluocinolone acetonide implant in patients with diabetic macular edema.

Background: There is a lack of consensus on the use of intravitreal corticosteroid therapies in patients with diabetic macular edema (DME) and prior vitrectomized eyes in clinical practice.

Methods: Retro-IDEAL was a 3-year retrospective, multicenter study in patients with chronic DME (i.e.

Ibrutinib restores immune cell numbers and function in first-line and relapsed/refractory chronic lymphocytic leukemia.

Ibrutinib positively modulates many T-cell subsets in chronic lymphocytic leukemia (CLL). To understand ibrutinib's effects on the broader landscape of immune cell populations, we comprehensively characterized changes in circulating counts of 21 immune blood cell subsets throughout the first year of treatment in patients with relapsed/refractory (R/R) CLL (n = 55, RESONATE) and previously untreated CLL (n = 50, RESONATE-2) compared with untreated age-matched healthy donors (n = 20). Ibrutinib normalized abnormal immune cell counts to levels similar to those of age-matched healthy donors.

Flat Lenses Based on 2D Perovskite Nanosheets.

Ultrathin flat lenses based on metasurfaces or metamaterials have shown great promise in recent years as essential components in nano-optical system, with capability of abrupt changes of light wavefronts. However, such structural designs require complex nanopatterns and a time-consuming nanofabrication process. In this regard, flat lenses are developed based on 2D perovskite nanosheets, using a cost-effective mask-free femtosecond direct laser writing system.

Different binding properties of two general-odorant binding proteins in Athetis lepigone with sex pheromones, host plant volatiles and insecticides.

Athetis lepigone (Alep) is a polyphagous pest native to Europe and Asia that has experienced major outbreaks in the summer maize area of China since 2011 and has shown evidence of resistance to some insecticides. Insect olfaction is crucial for recognition of sex pheromones, host plant volatiles and even insecticides, in which two general-odorant binding proteins (GOBPs) play important roles. To elucidate the functions of GOBPs in A.

Hierarchical CoO@N-Doped Carbon Composite as an Advanced Anode Material for Ultrastable Potassium Storage.

Cobalt oxide (CoO) delivers a poor capacity when applied in large-sized alkali metal-ion systems such as potassium-ion batteries (KIBs). Our density functional theory calculation suggests that this is due to poor conductivity, high diffusion barrier, and weak potassium interaction. N-doped carbon can effectively attract potassium ions, improve conductivity, and reduce diffusion barriers.

Self-Assembly of Integrin Ligands on the Apical Membrane Inhibits the Migration of Glioma Cells.

Malignant brain cancer remains challenging in treatment due to the highly invasive quality of gliomas. Inspired by the upregulated expression of integrin β1 subunits in tumors, we designed and synthesized an integrin-targeting self-assembling ligand based on a laminin-derived peptide that selectively forms nanofibrous microdomains on the apical membrane of glioma cells, inhibiting their migration and invasion.

[Monocentric, Retrospective, Comparative Study of the Safety and Effectiveness of Wound Modulation with Bevacizumab after Combined Cataract Surgery with Implantation of the CyPass Stent].

Background: Because of the known positive effect of bevacizumab (Avastin) on wound modulation in trabeculectomy, a retrospective study evaluated the safety and efficacy of wound modulation with Avastin following combined cataract surgery with CyPass stent.

Method: Retrospectively, the pre-, intra- and postoperative data (after three and six months) were collected from 484 eyes after combined surgery (n = 187 without Avastin, n = 297 with Avastin). The safety criteria were intraoperative complications and postoperative slit-lamp microscopic findings.

High-Yield Electrochemical Production of Large-Sized and Thinly Layered NiPS Flakes for Overall Water Splitting.

Achieving large-sized and thinly layered 2D metal phosphorus trichalcogenides with high quality and yield has been an urgent quest due to extraordinary physical/chemical characteristics for multiple applications. Nevertheless, current preparation methodologies suffer from uncontrolled thicknesses, uneven morphologies and area distributions, long processing times, and inferior quality. Here, a sonication-free and fast (in minutes) electrochemical cathodic exfoliation approach is reported that can prepare large-sized (typically ≈150 µm ) and thinly layered (≈70% monolayer) NiPS flakes with high crystallinity and pure phase structure with a yield ≈80%.

Three-year results from the Retro-IDEAL study: Real-world data from diabetic macular edema (DME) patients treated with ILUVIEN (0.19 mg fluocinolone acetonide implant).

Introduction: The Retro-IDEAL (ILUVIEN Implant for chronic DiabEtic MAcuLar edema) study is a retrospective study designed to assess real-world outcomes achieved with the ILUVIEN® (0.19 mg fluocinolone acetonide (FAc)) in patients with chronic diabetic macular edema (DME) in clinical practices in Germany.

Methods: This study was conducted across 16 sites in Germany and involved 81 eyes (63 patients) with persistent or recurrent DME and a prior suboptimal response to a first-line intravitreal therapy (primarily anti-VEGF intravitreal therapies).

[Treatment reality with ranibizumab in clinical routine use for patients with diabetic macular edema : 1‑year results of the German POLARIS cohort].

Background: Currently only few data are available on the treatment reality with ranibizumab in patients with diabetic macular edema (DME).

Material And Methods: POLARIS is an international observational study which included 983 patients who were treated with ranibizumab due to DME. The primary objective of the study was to investigate the influence of treatment and control intervals as well as resource utilization on the mean change in visual acuity.

Supraciliary Microstent in Refractory Open-Angle Glaucoma: Two-Year Outcomes from the DUETTE Trial.

Purpose: The aim of the study was to report longer term (24-month) outcomes for primary open-angle glaucoma (POAG) patients refractory to medical therapy implanted with a supraciliary microstent (CyPass Micro-Stent, Alcon) in the DUETTE clinical study.

Methods: Sixty-five eyes were enrolled in this multicenter single-arm trial. Enrolled patients had POAG and intraocular pressure (IOP) >21 mmHg at baseline on 1-4 ocular hypotensive medications.

Degradation of Two-Dimensional CHNHPbI Perovskite and CHNHPbI/Graphene Heterostructure.

Hybrid organic-inorganic metal halide perovskites have been considered as promising materials for boosting the performance of photovoltaics and optoelectronics. Reduced-dimensional condiments and tunable properties render two-dimensional (2D) perovskite as novel building blocks for constructing micro-/nanoscale devices in high-performance optoelectronic applications. However, the stability is still one major obstacle for long-term practical use.

[Healthcare Research of Cataract Surgery - Analysis of Patient's Satisfaction Following Cataract Surgery in Mecklenburg-Vorpommern/Germany].

The collection of pre-, peri- and postoperative data took place between 2005 and 2008, based on a contract between the social insurance company, AOK Mecklenburg-Vorpommern, and the outpatient cataract surgeons/centers in Mecklenburg-Vorpommern, Germany. The purpose of the contract was the monitoring of quality of cataract surgery in the outpatient healthcare system. We analysed 2952 datasets of 2952 eyes, remaining after exclusion of 109 datasets because of lack of plausibility and missing data (initially 3058 eyes with surgery in our centre).

[Change of Intraocular Pressure 10 Days Following Radical Prostatectomy for Prostate Cancer].

Background: Results of a retrospective study of perioperative changes in intraocular pressure (IOP) following radical prostatectomy (RPE) for prostate cancer.

Patients And Methods: In 25 consecutive patients, PSA (prostate specific antigen) and IOP were measured with Goldmann tonometry before and after a mean of 10 days following RPE. The data of three patients with proven glaucoma were evaluated separately.

[MALT Lymphoma of the Conjunctiva in a 13-year old Child--5-Year Relapse-free Follow-up Following Antibiotic Treatment].

Medical History: In February 2007, a 13-year old boy presented with a livid tumour in the lower conjunctival fornix of the left eye. OPHTHALMOLOGICAL FINDINGS: The tumor was salmon-coloured, bulging and elastic and filled the whole lower conjunctival fornix of the left eye. There was no other pathological finding in the left eye.

Experimental and Numerical Determination of the Local Temperature Distribution during Phacoemulsification and Comparison of Different Surgery Situations within Enucleated Porcine Eyes.

Phacoemulsification, a common treatment for cataract, is accompanied by cell damage at the corneal endothelium. Thermal exposure during treatment has been considered a reason for this damage, but a thorough experimental and theoretical assessment of the local temperature distribution inside the eye had not yet been conducted. Measurements in porcine eyes and a finite-element simulation enabled such an assessment and localized the highest temperature rise very close to the probe.

Supraciliary Micro-stent Implantation for Open-Angle Glaucoma Failing Topical Therapy: 1-Year Results of a Multicenter Study.

Purpose: To evaluate the safety and efficacy of a supraciliary micro-stent (CyPass Micro-Stent; Transcend Medical, Menlo Park, California, USA) for surgical treatment of glaucoma in patients refractory to topical medications.

Design: Multicenter, single-arm interventional study.

Methods: Patients with open-angle glaucoma (Shaffer Grade 3 and 4) and uncontrolled medicated intraocular pressure (IOP) >21 mm Hg at baseline and candidates for conventional glaucoma surgery were enrolled.

Broadband photodetectors based on graphene-Bi2Te3 heterostructure.

Recently, research on graphene based photodetectors has drawn substantial attention due to ultrafast and broadband photoresponse of graphene. However, they usually have low responsivity and low photoconductive gain induced by the gapless nature of graphene, which greatly limit their applications. The synergetic integration of graphene with other two-dimensional (2D) materials to form van der Waals heterostructure is a very promising approach to overcome these shortcomings.