Transconjunctival sutureless intrascleral intraocular lens fixation using intrascleral tunnels guided with catheter and 30-gauge needles.

We invented a new method for fixing an intraocular lens (IOL) in the scleral tunnel without using a wide conjunctival incision. Modified bent catheter needles were used to penetrate the IOL haptics through the sclerotomy sites. The IOL haptics were inserted into 30-guage (G) scleral tunnels guided by double 30-G needles piercing the sclera.

Intrascleral fixation technique using catheter needles and 30-gauge ultrathin needles: lock-and-lead technique.

Unlabelled: We report a new intrascleral fixation technique for a standard 3-piece posterior intraocular lens (IOL) using catheter needles and 30-gauge ultrathin needles instead of a special forceps and minimal intraocular manipulation in eyes without capsule support. Modified catheter needles are used to deliver the IOL haptic. The IOL haptic is secured extraocularly between the cannula and needle of a catheter needle and then advanced through the sclerotomy site.

Using catheter needles to deliver an intraocular lens for intrascleral fixation.

Unlabelled: A new method for delivering intraocular lens (IOL) haptics through sclerotomies for intrascleral fixation using catheter needles was evaluated in pig eyes. A bent catheter needle was used to penetrate the surgical corneal wound from the presumed sclerotomy. Extraocularly, the leading haptic of the IOL was fixated between the external tube and the internal needle of the catheter needle.

[A case of non-atherothrombotic cerebroretinal small vessel disease].

Background: There is an increasing interest in the relation between retinal artery abnormalities and cerebral small-vessel diseases (SVD), because retinal vessels share common properties with cerebral small vessels. We report a case of juvenile cerebrovascular disease presenting retinal vessel abnormalities, which clinically resembled cerebral autosomal dominant arteriopathy with stroke and ischemic leukoencephalopathy (CADASIL) but in which Notch3 gene mutations were not detected.

Case: A 42-year old woman was hospitalized at the department of Neurology in our hospital, complaining of headache and dysarthria.

Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization.

Purpose: To investigate the role of the leukocyte adhesion molecules CD18 and intercellular adhesion molecule (ICAM)-1 in the development of choroidal neovascularization (CNV).

Methods: Laser photocoagulation was used to induce CNV in wild-type C57BL/6J mice and species-specific counterparts with targeted homozygous disruption of the CD18 or ICAM-1 gene. Expression of CD18 and ICAM-1 after laser injury was assessed by immunostaining.