Publications by authors named "Hofer I"

Anesthetic gases contribute to global warming. We described a two-year performance improvement project to examine the association of individualized provider dashboard feedback of anesthetic gas carbon dioxide equivalent (CDE) production and median perioperative fresh gas flows (FGF) during general anesthetics during perioperative management. Using a custom structured query language (SQL) query, hourly CDE for each anesthetic gas and median FGF were determined.

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Background: Because the occurrence of metabolic syndrome (MetS) might contribute to childhood cancer survivor's excess risk of cardiovascular disease, the authors assessed the prevalence and determinants of MetS in the Dutch Childhood Cancer Survivor Study (DCCSS-LATER2) cohort.

Methods: In total, 2338 adult childhood cancer survivors (CCS) were cross-sectionally assessed for the prevalence of MetS, using the Lifelines cohort (N = 132,226 adults without a history of cancer) as references. The prevalence of MetS was clinically assessed using existing classifications, as well as an alternative method using dual-energy x-ray absorptiometry fat% instead of waist circumference to define abdominal adiposity.

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  • Childhood cancer survivors (CCS) have a higher likelihood of developing dyslipidemia, which is a significant risk factor for heart disease, compared to adults without a cancer history.
  • A study analyzed data from 2,338 CCS and found various lipid abnormalities in the survivors, indicating a prevalence of issues like high triglycerides and low HDL cholesterol.
  • Factors influencing dyslipidemia in CCS included age, sex, BMI, physical activity, and treatment history, highlighting the need for tailored health monitoring for these individuals.
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Background: The mechanism for recording International Classification of Diseases (ICD) and diagnosis related groups (DRG) codes in a patient's chart is through a certified medical coder who manually reviews the medical record at the completion of an admission. High-acuity ICD codes justify DRG modifiers, indicating the need for escalated hospital resources. In this manuscript, we demonstrate that value of rules-based computer algorithms that audit for omission of administrative codes and quantifying the downstream effects with regard to financial impacts and demographic findings did not indicate significant disparities.

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Postoperative urinary retention (POUR) is a common and distressing surgical complication that may be associated with the pharmacological reversal technique of neuromuscular blockade (NMB). This study aimed to investigate the impact that POUR has on medical charges. This was a retrospective observational study of adult patients undergoing select surgeries who were administered neuromuscular blockade agent (NMBA), which was pharmacologically reversed between February 2017 and November 2021 using data from the PINC-AIâ„¢ Healthcare Database.

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  • Increased intracranial pressure (ICP) ≥15 mmHg can harm neurological health, but measuring it traditionally requires invasive methods; researchers developed a new AI-based biomarker (aICP) using non-invasive extracranial waveform data instead.
  • The aICP was validated using an independent dataset and showed good performance metrics with an area under the receiver operating characteristic curve (AUROC) of 0.80 and an accuracy of 73.8%.
  • Further analysis indicated that higher aICP predictions are linked to specific health conditions, such as brain tumors and intracerebral hemorrhages, suggesting its potential clinical relevance.
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  • Intravenous fluids are crucial for managing acute kidney injury (AKI) after sepsis, but they can lead to fluid overload, prompting a need for a restrictive fluid strategy for certain patients.
  • A machine learning algorithm was developed and validated to identify sepsis patients with AKI who would benefit from receiving less than 500mL of fluids within 24 hours.
  • The algorithm suggested that 88.2% of patients in the validation cohort would benefit from a restrictive fluid approach, leading to higher rates of early and sustained AKI reversal and lower major adverse kidney events compared to those receiving more fluids.
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Background: Neuromuscular blockade (NMB) agents are a critical component of balanced anesthesia. NMB reversal methods can include spontaneous reversal, sugammadex, or neostigmine and the choice of reversal strategy can depend on various factors. Unanticipated changes to clinical practice emerged due to the COVID-19 pandemic, and a better understanding of how NMB reversal trends were affected by the pandemic may help provide insight into how providers view the tradeoffs in the choice of NMB reversal agents.

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Background: The risk of developing a persistent reduction in renal function after postoperative acute kidney injury (pAKI) is not well-established.

Objective: Perform a multi-center retrospective propensity matched study evaluating whether patients that develop pAKI have a greater decline in long-term renal function than patients that did not develop postoperative AKI.

Design: Multi-center retrospective propensity matched study.

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  • Malnutrition is often undiagnosed, leading to worse health outcomes and higher costs, prompting the Mount Sinai Health System to implement a machine learning model (MUST-Plus) for detection upon hospital admission.* -
  • The study analyzed data from nearly 67,000 adult patients to assess and improve the calibration of MUST-Plus, revealing significant miscalibration across different races and genders, particularly in its predictions.* -
  • After logistic recalibration, the model's accuracy improved for all patient subgroups, highlighting the importance of ongoing monitoring and adjustment to reduce healthcare disparities.*
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Background: Current classification for acute kidney injury (AKI) in critically ill patients with sepsis relies only on its severity-measured by maximum creatinine which overlooks inherent complexities and longitudinal evaluation of this heterogenous syndrome. The role of classification of AKI based on early creatinine trajectories is unclear.

Methods: This retrospective study identified patients with Sepsis-3 who developed AKI within 48-h of intensive care unit admission using Medical Information Mart for Intensive Care-IV database.

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  • Increased intracranial pressure (ICP) can lead to serious neurological problems, but requires invasive methods for monitoring, prompting the need for a non-invasive alternative.
  • The study focused on creating and validating an AI model that detects increased ICP using non-invasive physiological data from patients, rather than requiring direct ICP measurements.
  • Developed using data from an ICU database, the AI model demonstrated high accuracy and sensitivity in detecting elevated ICP, with promising results in external validation from a separate hospital dataset.
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Remote monitoring and artificial intelligence will become common and intertwined in anesthesiology by 2050. In the intraoperative period, technology will lead to the development of integrated monitoring systems that will integrate multiple data streams and allow anesthesiologists to track patients more effectively. This will free up anesthesiologists to focus on more complex tasks, such as managing risk and making value-based decisions.

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Background: International guidelines recommend quantitative neuromuscular monitoring when administering neuromuscular blocking agents. The train-of-four count is important for determining the depth of block and appropriate reversal agents and doses. However, identifying valid compound motor action potentials (cMAPs) during surgery can be challenging because of low-amplitude signals and an inability to observe motor responses.

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Study Objective: Perioperative neuromuscular blocking agents are pharmacologically reversed to minimize complications associated with residual neuromuscular block. Neuromuscular block reversal with anticholinesterases (e.g.

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Study Objective: Explore validation of a model to predict patients' risk of failing extubation, to help providers make informed, data-driven decisions regarding the optimal timing of extubation.

Design: We performed temporal, geographic, and domain validations of a model for the risk of reintubation after cardiac surgery by assessing its performance on data sets from three academic medical centers, with temporal validation using data from the institution where the model was developed.

Setting: Three academic medical centers in the United States.

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Background: Substantial effort has been directed toward demonstrating uses of predictive models in health care. However, implementation of these models into clinical practice may influence patient outcomes, which in turn are captured in electronic health record data. As a result, deployed models may affect the predictive ability of current and future models.

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Kidney disease affects 50% of all diabetic patients; however, prediction of disease progression has been challenging due to inherent disease heterogeneity. We use deep learning to identify novel genetic signatures prognostically associated with outcomes. Using autoencoders and unsupervised clustering of electronic health record data on 1,372 diabetic kidney disease patients, we establish two clusters with differential prevalence of end-stage kidney disease.

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  • Over the last 15 years, researchers have made a lot of progress in creating new lab tools called tumor-on-chip (ToC) systems that help study cancer better.
  • This overview combines the work of scientists and doctors to explain how ToC systems mimic real tumors and what challenges they still face.
  • ToC models might help find new cancer treatments and reduce the need for animal testing in research over the next decade.
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