Epidermal Collagen Reduction Drives Selective Aspects of Aging in Sensory Neurons.

Despite advances in understanding molecular and cellular changes in the aging nervous system, the upstream drivers of these changes remain poorly defined. Here, we investigate the roles of non-neural tissues in neuronal aging, using the cutaneous PVD polymodal sensory neuron in Caenorhabditis elegans as a model. We demonstrate that during normal aging, PVD neurons progressively develop excessive dendritic branching, functionally correlated with age-related proprioceptive deficits.

ST-GMLP: A concise spatial-temporal framework based on gated multi-layer perceptron for traffic flow forecasting.

The field of traffic forecasting has been the subject of considerable attention as a critical component in alleviating traffic congestion and improving urban services. Given the regular patterns of human activities, it is evident that traffic flow is inherently periodic. However, most of existing studies restrict themselves to recent historical observations and typically yield structurally and computationally complex models, which greatly limits the forecasting accuracy and hinders the application of models in realistic situations.

Intuition in Occupational Therapists' Clinical Reasoning: A Scoping Review.

This scoping review aimed to map the various facets of intuition in occupational therapy (OT), from its definitions, theoretical frameworks, epistemological paradigms to practical applications, highlighting its role in decision-making. Following the Joanna Briggs Institute methodology, a systematic search of five databases from 1990 to August 2023 identified 337 records related to OT and intuition. After removing duplicates and applying eligibility criteria, 22 studies were included.

Severe corneal manifestations of graft-versus-host disease: Experience of a tertiary referral center.

Purpose: Graft-versus-host disease (GVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). GVHD may affect several organs, including ocular manifestations, ranging from dry eye syndrome to sight-threatening corneal ulceration or perforation. Limited information is available about characteristics and treatments of ocular GVHD and its relation to general prognosis.

Meta-epidemiology and reporting characteristics of mapping reviews: a scoping review.

Objectives: To investigate the meta-epidemiology and reporting characteristics of mapping reviews.

Study Design And Setting: We conducted a scoping review of a sample of recent mapping reviews (2022-2023) by searching nine electronic databases and eleven institutional websites up to January 2024. A 28-item reporting checklist, developed by our team and based on existing guidance and methodological studies of mapping reviews, was employed to assess reporting characteristics.

Early infarct growth rate is associated with symptomatic intracranial hemorrhage after endovascular thrombectomy.

Background: Time elapsed from stroke onset and baseline infarct volume is influential on endovascular thrombectomy (EVT) outcomes.

Objectives: This study aimed to explore the utility of early infarct growth rate (EIGR) measured by apparent diffusion coefficient (ADC) in predicting symptomatic intracranial hemorrhage (sICH) of ischemic stroke patients after EVT.

Methods: We retrospectively analyzed patients from the prospectively maintained stroke registry admitted between January 2019 and March 2023, presenting with large vessel occlusive stroke in the anterior circulation.

Remodeling the Inflammatory and Immunosuppressive Tumor Microenvironment for Enhancing Antiangiogenic Gene Therapy of Colorectal Cancer.

Fusobacterium nucleatum (Fn), as an intestinal pathogenic bacterium, is closely related to the occurrence, progression, and limited therapeutic efficacy of colorectal cancer (CRC). The presence of Fn within CRC communities induces an inflammatory and immunosuppressive microenvironment while promoting new vessel formation. Therefore, developing novel methods to efficiently eliminate Fn and enhance the therapeutic outcomes against Fn-associated CRC is of great significance.

SNAI1 promotes epithelial-mesenchymal transition and maintains cancer stem cell-like properties in thymic epithelial tumors through the PIK3R2/p-EphA2 Axis.

Background: Thymic epithelial tumors (TETs) are infrequent malignancies that arise from the anterior mediastinum. Therapeutic options for TETs, especially thymic carcinoma (TC), remain relatively constrained. This study aims to investigate the oncogenic hub gene and its underlying mechanisms in TETs, as well as to identify potential therapeutic targets.

Analysis of Influencing Factors and Construction of Nomogram of School Bullying Suffered by Middle School Students in Beijing in 2022.

Purpose: School bullying has become increasingly serious among children, causing serious damage to their physical and mental health. Previous studies lacked data on bullying of middle school students in Beijing and rarely visualized the risks of bullying. This study investigated the situation and related risk factors of school bullying of middle school students in Beijing in 2022 and established a Nomogram prediction model to visualize the risk of school bullying for its prevention.

Fmoc-Pro-Phe-OMe dipeptide carbon sensor for simultaneous detection of chloramphenicol (CP) and furazolidone (FZ) toxic residues in food samples.

In this work, we fabricated the Fmoc-Pro-Phe-OMe modified carbon paste electrode (FPPO/MCPE) and used it for electrochemical detection of CP and FZ in a 0.1 M phosphate buffer solution (pH = 7). We characterized the Fmoc-Pro-Phe-OMe and applied it for the electrochemical detection of CP and FZ.

π-HuB: the proteomic navigator of the human body.

The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies.

Mo-Pb redox triggers self-enhanced removal and recovery of Pb with superselectivity.

Membrane-based electrodeposition (MED) has emerged as a promising approach for reversible removal-recovery of toxic but valuable Pb. However, limited by the low specificity of membrane deposition toward various heavy metal ions in MED, the selective removal of Pb remains an obstacle. Inspired by the soft-hard acid-base theory, here we developed a Pb-affinity electroactive membrane by incorporating MoS with the cation exchange membrane (CEM) to achieve a tandem Pb selective adsorption-deposition process.

Dual-Modal Dielectric Elastomer System for Simultaneous Energy Harvesting and Actuation.

Dielectric elastomers (DEs) have promising capabilities for soft electromechanical systems, including those for actuation and energy generation. However, their widespread application is restricted by electromechanical instability (EMI) and the requirement for high-voltage operation. This study presents a dual-modal DE system that effectively overcomes these limitations by leveraging a dual-membrane structure.

Radicular Dentin Thickness and Root Canal Morphology of Mandibular Incisors in Indian Subpopulation Using Cone Beam Computed Tomography.

Aim Using two classifications, this study assessed root morphology and canal configuration and measured the Dentin thickness (DT) and canal shapes. Methods Cone beam computed tomography (CBCT) with 400 Mandibular Incisors was collected and assessed for the number, length, curvature of roots, number of canals, bifurcation level, configurations based on Vertucci's and Ahmed's classification, DT and canal shape at 3, 6, 9 mm from the apex. The collected data was subjected to statistical analysis with a level of significance at p<0.

Knockdown of Alleviates Neuropathological Hallmarks and Cognitive Deficiency in a Model of Sporadic Alzheimer's Disease.

Objective: Recently, we revealed that triggering receptor expressed on myeloid cells-like 2 (TREML2) modulated inflammation by regulating microglial polarization and NLRP3 inflammasome activation. However, the role of TREML2 in Alzheimer's disease (AD) pathogenesis remains poorly understood. In this study, we tried to observe the impact of TREML2 on neuropathological hallmarks (including amyloid-β (Aβ) pathology, hyperphosphorylated tau and neuroinflammation) and cognitive deficiency in senescence-accelerated mouse prone substrain 8 (SAMP8) mice, an animal model of sporadic AD.

[Detection and characterization of the types of CYP21A1P/CYP21A2 and TNXA/TNXB fused genes by long-read sequencing among children with Steroid 21-hydroxylase deficiency].

Objective: To assess the diagnostic efficiency of long-read sequencing (LRS) for the determination of CYP21A1P/CYP21A2 and TNXA/TNXB fusion genotypes among children with 21-hydroxylase deficiency (21-OHD) and explore their clinical characteristics.

Methods: LRS sequencing was carried out on 30 children diagnosed with 21-OHD at the Department of Endocrinology, Fujian Children's Hospital between November 2022 and September 2023 by clinical symptoms or conventional Sanger sequencing combined with multiple ligation-dependent probe amplification (MLPA). The results of the two methods were compared.

A new species of Pristerophora Harold, 1869 (Coleoptera: Scarabaeidae: Melolonthinae) from Chile.

A new species of Macrodactylini (Coleoptera: Scarabaeidae: Melolonthinae), Pristerophora rothmanni new species, is described and illustrated based on male and female specimens collected in southern Chile. Natural history, habitat, and distributional data are given. An identification key for Pristerophora species is included.

A novel approach to enhancing biomedical signal recognition via hybrid high-order information bottleneck driven spiking neural networks.

Biomedical signals, encapsulating vital physiological information, are pivotal in elucidating human traits and conditions, serving as a cornerstone for advancing human-machine interfaces. Nonetheless, the fidelity of biomedical signal interpretation is frequently compromised by pervasive noise sources such as skin, motion, and equipment interference, posing formidable challenges to precision recognition tasks. Concurrently, the burgeoning adoption of intelligent wearable devices illuminates a societal shift towards enhancing life and work through technological integration.

Real-time analysis of liquid jet sample delivery stability for an X-ray free-electron laser using machine vision.

Automated evaluation of optical microscopy images of liquid jets, commonly used for sample delivery at X-ray free-electron lasers (XFELs), enables real-time tracking of the jet position and liquid jet hit rates, defined here as the proportion of XFEL pulses intersecting with the liquid jet. This method utilizes machine vision for preprocessing, feature extraction, segmentation and jet detection as well as tracking to extract key physical characteristics (such as the jet angle) from optical microscopy images captured during experiments. To determine the effectiveness of these tools in monitoring jet stability and enhancing sample delivery efficiency, we conducted XFEL experiments with various sample compositions (pure water, buffer and buffer with crystals), nozzle designs and jetting conditions.

Umbilical abscess caused by Helcococcus kunzii: a case report and literature review.

Introduction: Helcococcus kunzii is a commensal bacterium found in the human skin that seldom causes infection. While there is documentation of abscesses; such as foot, breast, and brain abscesses; caused by H. kunzii, there are no reports of its causing umbilical abscesses.

Modulation of morphine antinociceptive and rewarding effect by mirtazapine in an animal model of osteoarthritic pain.

People with chronic pain mitigate their suffering by the action of opioids. Adverse reactions aside, opioids are not exempt from potential complications like addiction and abuse, which have posed a global public health problem lately. Finding new therapeutic strategies to improve analgesia and to reduce opioid side effects has become a priority.

Structural regulation of alginate-based adsorbents based on different coordination configurations of metal ions and selective adsorption of copper ion.

To tackle the problem of developing efficient adsorbents for the selective removal of copper ions from wastewater, this investigation focused on the synthesis of Fe-GO/MMT/SA and Al-GO/MMT/SA copper ion adsorbent materials (Fe-GMS and Al-GMS), respectively, by merging two distinct metal ions (Fe(III) and Al(III)) with sodium alginate (SA), graphene oxide (GO), and montmorillonite (MMT). By introducing metal ions with different coordination configurations, the slit structure and pore density of the adsorbents can be effectively controlled, thereby enhancing the selectivity for copper ion adsorption. The results show that Fe-GMS has excellent adsorption capacity for Cu(II) compared with Al(III), and the adsorption capacity and distribution coefficient are 116.

Hard-to-reach communities in the rural Ecuador: A qualitative perspective on dietary habits and physical activity.

While many studies focus on urban areas, it's vital to understand health-related behaviours in rural communities. This paper aims to explore the factors that influence dietary habits and physical activity from the perspective of men and women of different ethnic groups living in a hard-to-reach rural area in Ecuador. We conducted 5 focus groups with 37 participants (26 women) from diverse cultural and ethnic backgrounds in marginalized communities in Esmeraldas.