Randomized preventive intervention for families: Adolescents' emotional insecurity and attachment to fathers.

The family communication project was a randomized preventive intervention designed to support families by improving interparental conflict behavior and the parent-child relationship, with the ultimate goal of decreasing emotional insecurity in the interparental relationship. Evidence for programs that may benefit father-adolescent attachment and adolescents' emotional insecurity in the marital context is a gap in the literature. According to the fathering vulnerability hypothesis, father-child attachment security might be expected to especially benefit from improvements in interparental conflict behavior.

A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity.

Functional tumor-specific cytotoxic T cells elicited by therapeutic cancer vaccination in combination with oncolytic viruses offer opportunities to address resistance to checkpoint blockade therapy. Two cancer vaccines, the self-adjuvanting protein vaccine KISIMA, and the recombinant oncolytic vesicular stomatitis virus pseudotyped with LCMV-GP expressing tumor-associated antigens, termed VSV-GP-TAA, both show promise as a single agent. Here we find that, when given in a heterologous prime-boost regimen with an optimized schedule and route of administration, combining KISIMA and VSV-GP-TAA vaccinations induces better cancer immunity than individually.

Reduced long-term memory in a rat model of 8 minutes ventricular fibrillation cardiac arrest: a pilot trial.

Background: Evaluating beneficial effects of potential protective therapies following cardiac arrest in rodent models could be enhanced by exploring behavior and cognitive functions. The Morris Water Maze is a well-known cognitive paradigm to test spatial learning and memory.

Results: Behavioral testing with the Morris Water Maze in Sprague-Dawley rats (300 ± 25 g) resuscitated after 8 min of ventricular fibrillation cardiac arrest was carried out 5 and 12 weeks after cardiac arrest (CA) and compared to results of naïve rats (CONTROL).

Noninvasive pulse waveform analysis in clinical trials: similarity of two methods for calculating aortic systolic pressure.

Background: Concerns persist about the validity of generalized transfer function-derived, aortic blood-pressure measurements during the administration of vasoactive agents in clinical trials. Hence, we compared this transfer-function method with another, which estimates aortic systolic pressure directly from the late systolic shoulder of the radial pressure wave, after administration of placebo, ramipril, or atenolol.

Methods: We recorded radial pressure pulse waveforms, using a commercially available system, in 30 subjects with >or=1 coronary risk factor in an acute study of ramipril at 10 mg and atenolol at 100 mg.

Occurrence of the ear-mite Raillietia auris in cattle in Austria.

We describe here the first documented case in Austria of the cattle ear mite Raillietia auris in a four-year-old dairy cow. The cow was mildly depressed, and keratoconjunctivitis was diagnosed in both eyes with Horner's syndrome in the left eye. The animal showed a mild head tilt to the left and a generalized ataxia with a tendency to move to the right side, which became exacerbated if the animal was blind-folded.