Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor.

The serine proteinase alpha-thrombin plays a pivotal role in the regulation of blood fluidity, and therefore constitutes a primary target in the treatment of various haemostatic disorders. Haemadin is a slow tight- binding thrombin inhibitor from the land-living leech Haemadipsa sylvestris. Here we present the 3.

[Quality assurance by improved cooperation structures. The example of decentralized early detection mammography].

The German Mammography Study investigated into quality assurance measures for screening mammography, proceeding in a decentralised manner and focussing especially on structure, process and outcome of the study. The field phase lasted for three years, and during this period the technology of the equipment used in mammography improved, also to the indicators of process and of early outcome. The annual interval of examinations was well received.

[Determinants of observer variability in early diagnostic mammography--a ROC analysis].

As part of the German mammographic study, the participating doctors were given test films of 30 histologically confirmed cases. Regarding the indications for biopsy there was good sensitivity (the median amongst 25 doctors was 0.87).

Computerized tomography of breast cancer and regional lymph nodes.

Technique, advantages and disadvantages of computerized tomographic (CT) mammography are described in various pre- and postoperative conditions. The value of CT mammography is discussed.

Growth rate of 147 mammary carcinomas.

In 147 cases of mammary carcinoma, 388 serial mammographies were performed before final treatment. The average retrospective observation time was 27 months with a range of two months to 11 years. The number of serial mammographies per case ranged between two and 11.

CT-visualization of an intraspinal osteoma-like mass in Paget's disease.

Neuroradiological examination in a case of polyostotic Morbus Paget with compression of the thoracic spinal cord was extended to spinal computed tomography. The use of radiography, myelography, and skeletal scintigraphy as regards diagnostic information is compared to CT. Obviously the use of CT provides a valuable completion for the evaluation of extradural space-occupying spinal lesions.

Hyperperfusion and enhancement in dynamic computed tomography of ischemic stroke patients.

The passage of contrast medium was observed using serial computed tomography (CT) in 24 stroke patients. Density--time profiles of various brain regions were plotted. In normal brain tissue, X-ray attenuation showed a maximum increase during the arterial phase (16.

[Spontaneous Visibility of the Mammary Ducts in Plain Mammography (author's transl)].

Mammary ducts become visible as negative contrast in the mammogram. This is caused by an increased contents of fat or oil in the mammary secretion. The secretion of lipides can indicate hormonal disregulation.

[Proposals for standardizing the image quality of mammography (author's transl)].

The radiography of phantoms is not sufficient to test the image quality of mammography. In addition, patients mammograms have to be evaluated using our proposed quality criteria.

[Introduction to x-ray diagnosis of primary malignant bone tumor (author's transl)].

Diagnosis of primary malignant bone tumors is based on a synopsis of X-ray findings, clinical symptoms, gross pathology and histology. Osteosarcoma, chondrosarcoma, fibrosarcoma and myelogenic sarcomas have a typical symptomatology and can be diagnosed in the radiograph by localisation, mode of extension, alterations of bone and periosteum.

X-ray therapy of primary bone tumors.

Radiotherapy of bone tumors can now be performed exclusively by megavolt therapy. Giant cell tumors hsould be resected. If the lesion is not completely resectable, surgery should be followed by the administration of a target dose of 3000 rads in 4-6 weeks.