Publications by authors named "Hoe-Myung Jung"
Article Synopsis
- Biliverdin IXβ reductase (BLVRB) is a key target for treating thrombocytopenia, as it relates to the management of reactive oxygen species (ROS).
- Olsalazine (OSA) has been identified as a strong inhibitor of BLVRB but is unstable due to degradation by gut bacteria enzymes, which complicates its use.
- To address this, a new compound called olsalkene (OSK) was developed, which maintains OSA’s effectiveness while being more stable and can inhibit BLVRB in different conditions, paving the way for new research on its role in blood disorders.
DJ-1, a protein encoded by PARK7 plays a protective role against neurodegeneration. Since its glyoxalase III activity catalyzing methylglyoxal (MG) to lactate was discovered, DJ-1 has been re-established as a deglycase decomposing the MG-intermediates with amino acids and nucleotides (hemithioacetal and hemiaminal) rather than MG itself, but it is still debatable. Here, we have clarified that human DJ-1 directly recognizes MG, and not MG-intermediates, by monitoring the detailed catalytic processes and enantiomeric lactate products.
View Article and Find Full Text PDFSafety evaluation of β-agarase preparations from Streptomyces coelicolor A3(2).
Regul Toxicol Pharmacol
February 2019
Recent studies on neoagarooligosaccharides prepared by hydrolyzing agar with β-agarase DagA produced from Streptomyces coelicolor A3(2) have enhanced our knowledge about the enzymatic utility of S. coelicolor. For safety evaluation, a crude extracellular protein containing DagA (crDagA) was prepared from the culture broth of S.
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