Irradiated laboratory animal diets: dominant lethal studies in the mouse.

In 4 separate dominant lethal experiments groups of mice of either Charles River CD1 or Alderley Park strains were fed laboratory diets (Oakes, 41B, PRD, BP nutrition rat and mouse maintenance diet No. 1). The diets were either untreated (negative control diets) or irradiated at 1, 2.

Plasma renin activity in patients after a subarachnoid hemorrhage--a possible predictor of outcome.

Plasma renin activity (PRA) was estimated in 23 patients during the 1st week after a subarachnoid hemorrhage (SAH) and in a control group of 6 postlaminectomy patients. Patients with altered levels of consciousness and neurological deficits had significantly higher levels of PRA than did patients who were alert and neurologically intact. The SAH patients were divided into three groups: (a) low renin (13 patients with a PRA of less than 1.

Hexamethylmelamine: an evaluation of its role in the treatment of ovarian cancer.

Hexamethylmelamine (HMM), NSC 13875, a synthetic agent structurally related to triethylenemelamine, has clinical antitumor activity and a role in the treatment of ovarian cancers of epithelial origin. Fifty-four patients, with International Federation of Gynecology and Obstetrics Stage III or IV carcinomas, previously untreated with chemotherapy or irradiation therapy, were treated with HMM (8 mg/kg/day) as a single agent at the M. D.

Social forces, ideology, and the domain of mental health services.

Public attitudes toward the mentally ill affect practices relating to treatment of mentally impaired persons. This has been true historically. The human rights movement and the community mental health movement have had a major impact on the care and treatment practices of the twentieth century.

Dominant lethal studies with the halogenated olefins vinyl chloride and vinylidene dichloride in male CD-1 mice.

The mutagenic activity of vinyl chloride (VC) and vinylidene dichloride (VDC) at three exposure levels was assessed in fertile male CD-1 mice with the dominant lethal test. Each compound was assessed in a separate study. Male mice were exposed by inhalation to VC at 3000, 10,000, and 30,000 ppm and to VDC at 10, 30, and 50 ppm for 6 hr/day for 5 days.

Comparative effects of physical training and diet in normalizing serum lipids in men with Type IV hyperlipoproteinemia.

The effect of milk physical training (PT) (group A), Type IV hyperlipoproteinemia (HLP) diet (group B), and PT plus Type IV HLP diet on serum lipids (group C) in 46 men with Type IV HLP was studied. Significant reductions in mean triglyceride (TG) levels from 163, 229, 196, to 136, 145, 116 mg/100 ml serum were found for groups A, B, and C, respectively. Following six weeks of intervention, cholesterol levels also dropped for all groups with the greatest reductions occurring in groups B and C.

Vinyl chloride: dominant lethal studies in male CD-1 mice.

The mutagenic activity of vinyl chloride (VC) at three exposure levels was assessed in fertile male CD-1 mice with the dominant lethal test. Male mice were exposured by inhalation to VC at 3000, 10,000 and 30,000 ppm for 6 h a day for 5 days. By comparison with control males exposed to air, no mutagenic effects on any maturation stage of spermatogeneisis in treated males were detected.

Competing responses and the processing of irrelevant information.

A number of studies have shown that performance of identification and discrimination tasks is detrimentally affected by irrelevant information, yet other studies have failed to find such decrements. It is suggested that these contradictory findings depend on whether S must make difficult discriminations among the relevant stimuli, the irrelevant stimuli, or between the relevant and irrelevant stimuli. The role of irrelevant information in these tasks is to enhance or amplify the competihg responses engendered by the difficult discriminations.

Some observations on the fine structure of the sinus gland of a land crab, Gecarcinus lateralis.

The dilated axon endings of the sinus glands of the brachyuran crab, Gecarcinus lateralis, are filled with homogeneously dense granules, each granule being bounded by a delicate membrane. The granules are of two orders of magnitude: 0.05 to 0.