Publications by authors named "Hoda H Said"
Article Synopsis
- Terminal sterilization of bone allografts using gamma radiation is necessary to lower infection risks, but it can compromise their mechanical properties.
- This research investigates the effect of free radical scavengers, hydroxytyrosol (HT) and alpha lipoic acid (ALA), on the structural and chemical changes in gamma-sterilized cortical bone.
- Results showed that using HT and ALA before gamma radiation helped maintain the chemical structure of bone, particularly the ratios of amide I and II and collagen cross-links, which were negatively affected by the radiation treatment.
Gamma radiation sterilization is the method used by the majority of tissue banks to reduce disease transmission from infected donors to recipients through bone allografts. However, many studies have reported that gamma radiation impairs the structural and mechanical properties of bone via formation of free radicals, the effect of which could be reduced using free radical scavengers. The aim of this study is to examine the radioprotective role of hydroxytyrosol (HT) and alpha lipoic acid (ALA) on the mechanical properties of gamma-sterilized cortical bone of bovine femur, using three-point bending and microhardness tests.
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