A hypothesis to explain how the sensory cortices respond in the appropriate sensory mode.

How does an area of sensory cortex recognize the specific nature of the sensory mode of the stimulus that arrives from the peripheral sensory receptor, when nerve impulses are only all-or-nothing action potentials? Work in animals has shown that an area of sensory cortex can learn in which mode to respond. A period of cortical learning is required for phantom limb phenomena to develop, and for the ocular blind to dream in the visual mode. Arguing from these facts I develop the hypothesis that within the sensory cortices there are neurons that learn by neurotropic factor transport from their sensory receptors to function as surrogates for those receptors, thus enabling sensory cortical response to be modally specific.

Chlorambucil allergy--a series of three cases.

Three cases of chlorambucil-related skin eruption in patients with low-grade non-Hodgkin's lymphoma are described. Cases were confirmed by exclusion of other drugs, rechallenge, skin testing and histology. One patient died due to florid erythema multiforme.

Transient severe hypoplastic anemia in Q fever.

A case of severe transient marrow hypoplasia as a complication of Q fever is described. This caused marked thrombocytopenia and anemia. The patient recovered fully over the period of 1 wk.

Acoustic desensitization of single-mode fibers utilizing nickel coatings.

The pressure sensitivity of the phase of light propagating in a single-mode fiber coated with a thin nickel jacket is determined both analytically and experimentally. The measured acoustic response of the fiber is found to be 1 order of magnitude lower than that of the bare fiber, in agreement with analytical predictions. The technique thus appears to be a promising way for desensitizing optical-fiber leads for use with fiber-optic sensors.

Fiber optic acoustic sensors with composite structure: an analysis.

Fiber optic acoustic sensors with composite structures are analyzed and shown to offer greatly increased acoustic sensitivity. The composite structure consists of an optical fiber coated with or embedded in an elastic material of lower elastic modulus. Sensitivity increases of 10-100 times are indicated.

Fiber-optic acoustic sensors with increased sensitivity by use of composite structures.

Fiber-optic acoustic sensors having sensitivity nearly 2 orders of magnitude greater than that of sensors using bare fiber are reported. These new devices utilize a composite structure wherein the fiber is embedded in a material of lower elastic modulus that serves to increase the stress, and hence the optical phase shift, in the fiber for a given pressure.

Fiber-optic sensing of pressure and temperature.

The use of a fiber-optic Mach-Zehnder interferometer to measure differences in temperature or pressure between two single-mode fiber arms is described. Temperature or pressure changes are observed as a motion of an optical interference fringe pattern. Values are calculated for the pressure and temperature dependence of the fringe motion.

Hodgkin's disease: results of treatment with combination chemotherapy.

Combination chemotherapy, which consisted of nitrogen mustard, a vinca alkaloid, procarbazine, and prednisone, was given to 60 patients with disseminated or recurrent Hodgkin's disease. A complete remission of disease was observed in 41 patients, with a median duration of 35+ months. The longest continuing remission was 89 months, and 52% of patients who achieved a complete remission were alive five years from the start of treatment.

Unidirectional star coupler for single-fiber distribution systems.

The design and construction of a unidirectional star coupler for single-fiber distribution systems are described. A rectangular mixing section is required to obtain uniform output distribution. Four-port stars have been constructed with losses only (1/2) to 1 dB greater than packing fraction.

Mode dispersion in diffused channel waveguides by the effective index method.

The effective index method for calculating waveguide mode dispersion is reviewed and applied to uniform rectangular optical waveguides with both small and large index differences. The results are shown to be at least as accurate as other approximate techniques. The effective index method is then applied to channel waveguides assuming 1-D and 2-D diffusion.

[Results of treatment for laryngeal carcinoma in Würzburg].

From 1960 through 1972, altogether 418 patients with laryngeal carcinoma have been treated at Würzburg, 333 = 82% of these by primary radiation therapy with Co-60 gamma-rays. The results are reported and analyzed in dependence on prognostic factors as tumor site and extension, formation of metastases and age of the patient. Five-year survival of primarily irradiated cases from 1960 to 1967; Glottic T1 = 90%, T2 = 70%, T3 -31%.

Advanced non-Hodgkins' lymphomas: response to treatment with combination chemotherapy and factors influencing prognosis.

Response to combination chemotherapy with cyclophosphamide, vincristine and prednisone (COP) and specific factors influenceing prognosis were evaluated in 70 patients with stage III or IV non-Hodgkin's lymphomas. Complete remissions (CR) were observed in 40% of patients, with a total response rate of 88%. The median duration of CR was 8 months, but 50% of patients were in continuing CR.