Insights into the intraparticle morphology of dendritic mesoporous silica nanoparticles from electron tomographic reconstructions.

Hypothesis: Although many synthetic pathways allow to fine-tune the morphology of dendritic mesoporous silica nanoparticles (DMSNs), the control of their particle size and mesopore diameter remains a challenge. Our study focuses on either increasing the mean particle size or adjusting the pore size distribution, changing only one parameter (particle or pore size) at a time. The dependence of key morphological features (porosity; pore shape and pore dimensions) on radial distance from the particle center has been investigated in detail.

Morphology-transport relationships for SBA-15 and KIT-6 ordered mesoporous silicas.

Quantitative morphology-transport relationships are derived for ordered mesoporous silicas through direct numerical simulation of hindered diffusion in realistic geometrical models of the pore space obtained from physical reconstruction by electron tomography. We monitor accessible porosity and effective diffusion coefficients resulting from steric and hydrodynamic interactions between passive tracers and the pore space confinement as a function of λ = d/d (ratio of tracer diameter to mean mesopore diameter) in SBA-15 (d = 9.1 nm) and KIT-6 (d = 10.

Morphology-transport relationships in liquid chromatography: Application to method development in size exclusion chromatography.

We present relationships between the multiscale structure and the separation properties of size exclusion chromatography (SEC) columns. Physical bed reconstructions of wall and bulk regions from a 2.1 mm i.

[Multidisciplinary treatment of chronic pain--opportunities and challenges for collaboration between psychosomatic medicine and physiotherapy].

Chronic pain is often associated with inefficient treatments attempts and a significant impairment of quality of life. The treatment of patients with chronic pain has been a major challenge for all disciplines concerned; none has convincingly shown that their approach achieves the goal of a pain free life. Multimodal pain management programs are characterised by a joint effort of somatic medicine, physiotherapy, and psychology or psychotherapy to cooperate in a shared model of diagnosis and treatment for chronic pain patients.

Physical training for intermittent claudication: a comparison of structured rehabilitation versus home-based training.

In a non-randomized, open-label study results after a structured institution-based peripheral arterial occlusive disease (PAD) rehabilitation program were compared with the results of training at home. Three groups were compared: group 1 (n = 19) PAD rehabilitation; group 2 (n = 19) PAD rehabilitation + clopidogrel 75 mg once daily; group 3 (n = 21) home-based training. The training period was 3 months for all groups, which was followed by a 3-month observation phase (without prescribed training).

[The value of walking exercise in treatment of intermittent claudication].

Physical training is one of the basic measures for all patients suffering from a generalized atherosclerosis. Specific training forms for PAD patients include home-based and structured, organized physical training programs; these are discussed and the results of meta-analyses presented. Whereas the published materials available for a home-based training is non-conclusive, structured training programs will lead to a statistically significant and clinically relevant improvement of a PAD patients' functional capacity.

Collaborative clinical laboratory evaluation of an individual MIC strip system.

Susceptibility results obtained with individualized MIC strips (MICRO-MIC) agreed with the standard microdilution broth method at a level of 96% or greater for each of the 10 antimicrobial agents tested.

[Altitude edema in the Swiss Alps. Observations on the incidence and clinical course in 50 patients 1980-1984].

In the Swiss Alps 50 patients with high altitude edema (high altitude pulmonary edema and/or high altitude cerebral edema) had to be rescued by helicopter during the period 1980-1984. The development, clinical picture and clinical course have been analyzed retrospectively. The patients were 49 men and one woman, generally in good health and well trained.