[Viral hepatitis at the beginning of the 21st century--value of liver biopsy in the context of development of new non-invasive diagnostic methods and in relation to the modern therapy of chronic viral hepatitis].

The rapid progress in the development of virostatic agents over the past 15 years has changed chronic viral hepatitis from causally incurable diseases to diseases that may be treated or even cured. But, the treatment is a long-term process and it remains very expensive. Therefore, it is important to establish the correct diagnosis with the exact stratification of the disease (in terms of serological findings, regarding the activity of the inflammation and alterations of liver parenchyma) to determine the appropriate treatment schedule.

[Infectious diseases in problem drug users hospitalized in the infectious ward of the Motol University Hospital in 2002-2005].

Background: To survey infectious diseases in intravenous drug users and to provide basic information on disease course in this subpopulation.

Material And Methods: A retrospective study of all inpatient intravenous drug users, from 2002 to 2005. The obtained data were sorted according to the main diagnosis and final results of chronic infections were achieved by outpatient follow-up.

[Infectious diseases of drug users in the Czech Republic].

Background: Prevalence of drug users in Czech Republic remains stable in the last years (about 22 to 38 thousands). Two thirds of drug users administer the drug intravenously, what is the most risky way of application. It is also why the number of infectious diseases in that community has not decreased.

Changes in lymphocyte subpopulations and CD3+/DR+ expression in sepsis.

Objective: To detect lymphocyte subpopulations and CD3+/DR + expression in sepsis.

Methods: In a prospective clinical study we evaluated subpopulations of lymphocytes and percentage of CD3+/HLA-DR+ lymphocytes using two-color flow cytometry in 40 patients with sepsis and compared them with 34 healthy adults.

Results: Septic patients, when compared with healthy controls, have significantly lower percentage and absolute numbers of total T lymphocytes and CD4 T lymphocytes (P < 0.

[Association of class I HLA antigens with invasive meningococcal disease].

Background: The majority of meningococcal infections are characterized by nasopharyngeal carriership. In some patients invasive disease with a mild course develops, while some cases have a lethal outcome. The reasons of this wide variation range are not clear.

[Clinical experience with treatment of childhood infections using sultamicillin--Unasyn (Pfizer)].

The authors treated 24 children, the majority with respiratory infections and infections of the urinary tract, with sultamicillin, incl. 22 where an oral suspension was used and in two children therapy was started with i.v.

[The clinical picture and etiology of meningoencephalitis in hospitalized patients in 1986].

In 1986 in the CSR 978 cases of acute meningoencephalitis were notified, incl. 184 in the capital. In a group of 129 patients aged 1 to 63 years hospitalized at the First Clinic for Infectious Diseases in Prague-Bulovka (Paediatric Faculty Charles University) in 1986 the authors investigated the clinical course of acute meningoencephalitis in relation to the causal agent of the disease.