Optimization of Culture Conditions for High Cell Productivity and Astaxanthin Accumulation in Vietnam's Green Microalgae HB and a Neuroprotective Activity of Its Astaxanthin.

Background: , a green microalga, is a rich source of natural astaxanthin and a potent antioxidant with high commercial value. This study investigates the biological characteristics and potential of HB isolated from Hoa Binh, Vietnam, for growth and astaxanthin accumulation using a two-phase culture method.

Methods: HB was cultured in a C/RM medium at 25 °C, and morphological characteristics were examined.

Co-encapsulated astaxanthin and kaempferol nanoparticles: fabrication, characterization, and their potential synergistic effects on treating non-alcoholic fatty liver disease.

Astaxanthin and kaempferol, renowned natural compounds, possess potent antioxidant properties and exhibit remarkable biological activities. However, their poor water solubility, low stability, and limited bioavailability are the primary bottlenecks that restrict their utilization in pharmaceuticals and functional foods. To overcome these drawbacks, this study aims to fabricate astaxanthin/kaempferol co-encapsulated nanoparticles and investigate their synergistic effects on reducing the risk of stress oxidation, chronic inflammation, and lipid accumulation in RAW264.

Isolation of Fucoxanthin from Montagne, 1845 Seaweed in Vietnam and Its Neuroprotective Activity.

Fucoxanthin extracted and purified from Vietnamese Montagne, 1845 exhibits various biological activities. In this study, the ability of fucoxanthin to inhibit acetylcholinesterase (AChE), the antioxidant activities, and the expression of antioxidant enzymes were investigated. Fucoxanthin isolated from Vietnamese showed no cytotoxic effects; moreover, it exhibited AChE inhibitory activity (with an IC value of 130.

Chemical constituents from the heterotrophic marine microalgae sp. SC145 and their antimicrobial activities.

One new indol, -methoxymethyltryptophol (), one new phenolic, (2 )-2-(4-hydroxyphenyl)ethyl 2-hydroxy-3-phenylpropanoate () and fifteen known compounds () were isolated from the methanol extract of the fermentation of marine microalgae sp. SC145. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis, HR-ESI-MS, quantum chemical calculation methods and by comparing their NMR data with those reported in the literature.

Characterization and Optimization of Culture Conditions for sp. SC145 Isolated from Sand Cay (Son Ca) Island, Vietnam, and Antioxidative and Neuroprotective Activities of Its Polyunsaturated Fatty Acid Mixture.

is a heterotrophic marine microalga that has potential industrial applications. The main objectives of this study were to isolate an strain from Sand Cay (Son Ca) Island, Vietnam, optimize its culture conditions, determine its nutritional composition, extract polyunsaturated fatty acids (PUFAs) in the free (FFA) and the alkyl ester (FAAE) forms, and evaluate the antioxidation and neuroprotection properties of the PUFAs. sp.

Genome analysis of the heterotrophic microalga Thraustochytrium sp. TN22 to identify genes involved in exopolysaccharide and carotenoid biosynthesis pathways.

In this study, the genome of Thraustochytrium sp. TN22, a heterotrophic marine microalga, was sequenced, assembled and annotated using the Illumina NovaSeq 6000, PacBio RS II and MinION platform to identify genes and EPS and carotenoid biosynthesis pathways. The genome of Thraustochytrium sp.

Biocharacteristics and draft genome sequence of Halomonas hydrothermalis C22, a pyruvate-producing halophilic bacterium isolated from a commercial Spirulina culture in Vietnam.

Halophilic bacteria are receiving increasing attention for industrial chemical production processes due to their unique properties. Herein, an alkaliphilic and halophilic bacterium was isolated from a commercial Spirulina culture at Nghe An province in Vietnam and found to secrete pyruvate. Pyruvate is widely used as a starting material in the industrial biosynthesis of pharmaceuticals, and is employed for production of crop protection agents, polymers, cosmetics, and food additives.

Preparation and Evaluation of Cream Mask from Vietnamese Seaweeds.

Seaweed is rich source of natural bioactive compounds that could be exploited as functional ingredient for cosmetic applications. The aim of this study was to evaluate the biochemical compositions and bioactivities of 10 seaweeds collected from coastal waters of Vietnam. The present study also prepared and evaluated cream mask from mixture of seaweeds extracted with water.

Squalene promotes cholesterol homeostasis in macrophage and hepatocyte cells via activation of liver X receptor (LXR) α and β.

Objective: To examine the effect of squalene on liver X receptors (LXRs) that regulate target genes associated with reverse cholesterol transport and thus control whole-body cholesterol homeostasis.

Results: To examine the effect of squalene on liver X receptors (LXRs) that regulate target genes associated with reverse cholesterol transport and thus control whole-body cholesterol homeostasis. Squalene significantly stimulated the transactivation of liver X receptor modulator LXRα and LXRβ.

Squalene isolated from Schizochytrium mangrovei is a peroxisome proliferator-activated receptor-α agonist that regulates lipid metabolism in HepG2 cells.

Objective: Peroxisome proliferator-activated receptor-alpha (PPARα) is a nuclear receptor that has critical roles in the treatment of atherosclerosis, hyperlipidemia and hepatic steatosis.

Results: Squalene is a novel nature PPARα agonist, identified from reporter gene assay and qPCR analysis. Cultured hepatocytes stimulated with squalene exhibited significantly decreased cellular triacylglycerols and cholesterol concentrations, while cellular uptake of fatty acids was increased.

Phylogenetic analyses of Prorocentrum spp. and Alexandrium spp. isolated from northern coast of Vietnam based on 18S rDNA sequence.

Some species of marine dinoflagellates belonging to genera Alexandrium and Prorocentrum have been responsible for paralytic shellfish poisoning (PSP) and diarrheic shellfish poisoning (DSP), respectively Morphological and molecular studies of 4 species including Alexandrium sp. 5, Alexandrium sp. 16, Prorocentrum sp.

Nutritional analysis of Vietnamese seaweeds for food and medicine.

Vietnamese edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Vietnamese living in the coastal have traditionally utilized seaweeds species as food supplement and herbal medicine. They consumed seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup.