Publications by authors named "Hoang Thao Nghi"
Article Synopsis
- MitoNEET, an iron-sulphur protein in the mitochondrial outer membrane, is linked to the drug pioglitazone but its exact molecular function remains unclear.
- Researchers identified a specific site for nitric oxide (NO) access to the mitoNEET's [2Fe-2S] cluster and found that both oxygen and pioglitazone can block this access.
- This discovery suggests a role for mitoNEET in mitochondrial signal transduction related to hypoxia, revealing new insights into how [Fe-S] clusters may function in signaling processes in eukaryotic cells.
Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism.
Curr Opin Chem Biol
October 2023
Article Synopsis
- - Iron-sulfur clusters ([FeS]) have been crucial for life on Earth since prebiotic times, contributing to essential biological processes such as respiration and immune response.
- - The text focuses on three specific [FeS] proteins involved in the innate immune response and their influence on oncogene activity and metabolism related to cancer.
- - Future research on [FeS] clusters is vital for uncovering their roles in cancer development, which could lead to new targets for anticancer drugs.