Antihypertensive Effects of Makino via NO/cGMP Pathway and Ca and K Channels.

Studies have demonstrated the therapeutic effects of plants. This study was undertaken to reveal the antihypertensive properties of leaf ethanolic extract (LEL). Aorta segments of Sprague-Dawley rats were used to study the vasodilatory effect of LEL, and the mechanisms involved were evaluated by treating specific inhibitors or activators that affect the contractility of blood vessels.

Effect of Fruit Extract for Endothelium-Independent Vasorelaxation and Blood Pressure Lowering in Rats.

(TJ) fruit, is a herb that is traditionally used for erectile dysfunction (ED). Given the shared mechanisms of ED and hypertension through vascular smooth muscle, we hypothesized that TJ would be effective in vasodilation and blood pressure reduction. This study confirmed the authenticity of TJ samples via DNA barcoding and quantified the main active compound, torilin, using HPLC.

Vasorelaxant and Hypotensive Effects of in Rats.

Previous studies have revealed the medicinal and therapeutic effects of . However, no studies have focused on the antihypertensive effects of . Therefore, we aimed to determine the vasorelaxant and hypotensive effects of 50% ethanolic extract (GCE).

Vasorelaxant and Blood Pressure-Lowering Effects of Fruit Ethanol Extract in Sprague Dawley and Spontaneously Hypertensive Rats.

(L.) Cusson, a member of the family, is rich in coumarins, such as imperatorin and osthole. fruit (CM) has a broad range of therapeutic potential that can be used in anti-bacterial, anti-cancer, and sexual dysfunction treatments.

Blood-Pressure-Lowering and Endothelium-Dependent Vasorelaxant Effects of Nutgall Tree in Rats.

Hypertension is the crucial modifiable risk factor for cardiovascular diseases, and efforts to identify functional foods that are effective for hypertension control are increasing. The nutgall tree (NT, Mill.) is used in traditional medicine and food because of its medicinal value.

Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade.

Natural compounds, known for diverse pharmacological properties, have attracted attention as potential sources for hypertension treatment. Previous studies have revealed the hypotensive effect and vascular relaxation of prunetin, a natural compound derived from . However, the potential blood pressure-lowering and vasorelaxant effects of sakuranetin, another representative compound found in plants belonging to the genus , have remained unexplored.

Hypotensive and Endothelium-Dependent Vasorelaxant Effects of Grayblue Spicebush Ethanol Extract in Rats.

Hypertension is one of the most common chronic diseases, and its prevalence is increasing worldwide. (Siebold & Zucc.) Blume, known as grayblue spicebush (GS), has been used as food and for medicinal purposes; however, studies about its hypotensive or vasorelaxant effects are lacking.

Hypotensive and Vasorelaxant Effects of Sanguisorbae Radix Ethanol Extract in Spontaneously Hypertensive and Sprague Dawley Rats.

Hypertension requires proper management because of the increased risk of cardiovascular disease and death. For this purpose, functional foods containing tannins have been considered an effective treatment. Sanguisorbae radix (SR) also contains various tannins; however, there have been no studies on its vasorelaxant or antihypertensive effects.

Proximal Junctional Kyphosis or Failure After Adult Spinal Deformity Surgery - Review of Risk Factors and Its Prevention.

Proximal junction kyphosis (PJK) is a common imaging finding after long-level fusion, and proximal junctional failure (PJF) is an aggravated form of the progressive disease spectrum of PJK. This includes vertebral fracture of upper instrumented vertebra (UIV) or UIV+1, instability between UIV and UIV+1, neurological deterioration requiring surgery. Many studies have reported on PJK and PJF after long segment instrumentation for adult spinal deformity (ASD).

Vascular Relaxation and Blood Pressure Lowering Effects of in Rats.

Siebold et Zuccarini is mainly consumed as processed fruits in beverages, vinegar, alcohol, or fruit syrup; studies have reported various functional effects. Many pharmacological and functional studies exist on fruit extracts or processed foods using fruits, however, efficacy studies on various parts of , including the bark, branches, flowers, and leaves, have not been sufficiently conducted. A previous study revealed that a 70% ethanol extract of branches induced vascular endothelium-dependent vasorelaxant effects in rat thoracic aortic rings.

Davidone C Induces the Death of Hepatocellular Carcinoma Cells by Promoting Apoptosis and Autophagy.

Davidone C is a newly discovered flavonoid compound purified from the ethyl acetate-soluble fraction of (Franch.) Skeels. This study explored the anti-tumor activity of davidone C on hepatocellular carcinoma HepG2 and Bel-7402 cells and its mechanism through MTT method, morphological observation, flow cytometry and Western blotting.

Effect of Co-Administration of Curcumin with Amlodipine in Hypertension.

Curcumin, a curcuminoid known as the main bioactive compound of turmeric, is used in foods, cosmetics, and pharmaceutical products. Amlodipine is a general antihypertensive drug used in combination with various other antihypertensive agents. To date, no studies have examined the effects of the co-administration of amlodipine with curcumin.

Davidones F and G, Two Novel Flavonoids from (Franch.) Skeels.

An unprecedented novel flavanone davidone F () with a seven-membered ring side chain, and a novel flavanonol davidone G (), along with 11 known flavonoids, were isolated from the ethyl acetate fraction of (Franch.) Skeels. Their planar structures were established by UV, IR, HRESIMS, 1D and 2D NMR data.

Chemical Constituents from Roots of (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities.

(Franch.) Skeels is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of , a chemical investigation was thus performed.

Anti-esophageal Cancer Effect of Corilagin Extracted from Phmllanthi Fructus via the Mitochondrial and Endoplasmic Reticulum Stress Pathways.

Headings Ethnopharmacological Relevance: Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) is a tannin isolated from the traditional ethnopharmacological plant Phmllanthi Fructus, which is widely used in not only traditional Chinese medicine but also tropical and subtropical medicine to ameliorate various diseases.

Aim Of The Study: This study was designed to isolate the potential anti-esophageal cancer (EC) component corilagin from Phmllanthi Fructus and explain its anti-EC mechanism.

Materials And Methods: Corilagin was isolated from Phmllanthi Fructus by extraction and chromatographic procedures, and its anti-esophageal cancer effect was evaluated by in vitro and in vivo experiments.

New flavonoids from the roots of Sophora davidii (Franch.) Skeels and their glucose transporter 4 translocation activities.

Five new flavanones, davidones A-E (1-5), one new isoflavonoid, cyclolicoisoflavones A (8), together with seven known compounds were isolated from the petroleum ether and the ethyl acetate fractions of the roots of Sophora davidii (Franch.) Skeels. The structures of new compounds were established by 1D and 2D NMR and MS data.

Vasorelaxant effects of 50 commonly used traditional herbal prescriptions on isolated rat aortic rings.

Objective: To investigate the vasorelaxant activities of 50 common traditional herbal prescriptions (THPs) on isolated rat aortic rings.

Methods: An electric extractor was used to extract THPs. Rat aortic rings were precontracted using phenylephrine in organ chambers containing Krebs-Henseleit solution.

Vasorelaxant Effect of (Siebold) Siebold & Zucc. Branch through the Endothelium-Dependent Pathway.

Korean plum ( (Siebold) Siebold & Zucc.) has long been used as a health food or herbal medicine in Asia. Previous studies have shown that several plants of the genus have vasodilatory and antihypertensive effects; we hypothesized that branches may have a vasorelaxant effect.

Endothelium-Dependent Vasorelaxant Effect of Branch on Isolated Rat Thoracic Aorta.

Peach ( (L.) Batsch) is a popular fruit consumed by people worldwide, owing to its pleasant flavor and high mineral nutrient content. A few plants from the genus , such as , , and have shown vasorelaxant and vasodilatory effects, to date, no study has investigated the vasorelaxation effects of the branch extract (PPE).

Thirteen-Week Oral Toxicity Study of HVC1 in Rats.

Studies on the safety of herbal medicine are essential for the development of new drugs. The aim of this study was to evaluate the no-observed-adverse-effect-level (NOAEL) of HVC1 (Gamisamhwangsasim-tang, a 30% ethanol extract of a mixture of Pruni Cortex, Scutellariae Radix, Coptidis Rhizoma, and Rhei Rhizoma) and identify its target organs after oral administration to Sprague-Dawley (SD) rats repeatedly for 13 weeks. Three test groups were treated with HVC1 at a dose of either 500 (low-dose), 1,000 (middle-dose), or 2,000 (high-dose) mg/kg/day.

Prunetin Relaxed Isolated Rat Aortic Rings by Blocking Calcium Channels.

Prunetin, a component of herbal medicines and various foods, such as pea, peach, cherry, and , is a useful pharmacological compound. We previously reported the potent vasorelaxant effect of the bark of . Therefore, we investigated the vasorelaxant activities of prunetin on isolated rat aortic rings and hypotensive activity on spontaneously hypertensive rats (SHR) in this study.

Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats.

Historically, traditional herbal medicines (THMs) have been the conventional treatment strategy in the Korean medical system for treating many diseases. However, THMs have rarely been used to treat hypertension, and moreover few studies have investigated the interaction of blood pressure with the coadministration of synthetic antihypertensives. We aimed to evaluate the vasorelaxant and hypotensive effects of the traditional herbal prescription Cheonwangbosimdan (CWBSD; "Tianwangbuxindan" in Chinese) and the combination of CWBSD with amlodipine.

Experimental research of hypotensive and hypolipidemic effects with Modified Sanhuang Xiexin Decoction ().

Objective: To investigate the hypotensive and hypolipidemic effects of Modified Sanhuang Xiexin Decoction (, HVC1), a herbal prescription for the vascular diseases in Chinese medicine and evaluate the acute and subchronic oral toxicities.

Methods: Fifty-six spontaneous hypertensive rats (SHRs) were used to investigate the hypotensive and hypolipidemic effect of HVC1. Rats in the normal group (n=8) were fed with normal diet.

Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings.

Background: Hypertension is one of the most important risk factors for cardiovascular disease (CVD) and a worldwide problem. Despite increases in the development of synthetic drugs for hypertension treatment, the rate of untreated and uncontrolled hypertension remains high. These drugs are effective, but can also cause side effects.

HVC1 ameliorates hyperlipidemia and inflammation in LDLR mice.

Background: HVC1 consists of Coptidis Rhizoma (dried rhizome of Coptischinensis), Scutellariae Radix (root of Scutellariabaicalensis), Rhei Rhizoma (rhizome of Rheum officinale), and Pruni Cortex (cortex of Prunusyedoensis Matsum). Although the components are known to be effective in various conditions such as inflammation, hypertension, and hypercholesterolemia, there are no reports of the molecular mechanism of its hypolipidemic effects.

Methods: We investigated the hypolipidemic effect of HVC1 in low-density lipoprotein receptor-deficient (LDLR) mice fed a high-cholesterol diet for 13 weeks.