Publications by authors named "Ho Yee Cheung"
Over-interpretation of findings in diagnostic accuracy studies of infectious diseases.
Clin Microbiol Infect
August 2023
Objectives: To assess the prevalence of overly positive interpretation, also called 'spin',-of results in diagnostic accuracy studies of infectious diseases and to identify suggestions for improvement.
Methods: A PubMed search was performed to identify diagnostic accuracy studies of infectious diseases published between January and March 2019. Each article was assessed by two authors independently to identify study characteristics and forms of actual and potential over-interpretation.
Article Synopsis
- Cangrelor is the only intravenous P2Y inhibitor used when oral options aren't timely for patients having percutaneous coronary intervention (PCI), mainly in STEMI cases in a Dutch study from 2015 to 2021.
- In a cohort of 146 patients, the 30-day mortality rate was 25.3%, with a low incidence of stent thrombosis (1.7%) and major bleeding (12.5%) reported.
- Notably, cardiac arrest upon presentation was identified as a significant predictor of 30-day mortality, indicating that high-risk patients were effectively managed with cangrelor despite their critical condition.
Article Synopsis
- Immunotherapy that uses short immunogenic peptides from autoantigens shows promise in restoring immune tolerance in type 1 diabetes, with a study focused on proinsulin peptides in patients.
- The treatment was well tolerated and did not lead to increased hypersensitivity, while placebo patients experienced a decline in insulin reserve and an increase in insulin usage over time.
- Results indicated that the treated patients maintained C-peptide levels and exhibited signs of immune modulation, suggesting that proinsulin peptide therapy could safely preserve β cell function in type 1 diabetes.
Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine.
Evid Based Complement Alternat Med
August 2015
This paper reviews the latest understanding of biological and pharmacological properties of osthole (7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one), a natural product found in several medicinal plants such as Cnidium monnieri and Angelica pubescens. In vitro and in vivo experimental results have revealed that osthole demonstrates multiple pharmacological actions including neuroprotective, osteogenic, immunomodulatory, anticancer, hepatoprotective, cardiovascular protective, and antimicrobial activities. In addition, pharmacokinetic studies showed osthole uptake and utilization are fast and efficient in body.
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