Publications by authors named "Ho Sub Lee"

Heart failure, a major public health issue, often stems from prolonged stress or damage to the heart muscle, leading to cardiac hypertrophy. This can progress to heart failure and other cardiovascular problems. Doxorubicin (DOX), a common chemotherapy drug, and isoproterenol (ISO), a β-adrenergic agonist, both induce cardiac hypertrophy through different mechanisms.

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  • Myocardial infarction (MI) can lead to heart failure and the study tested the traditional Korean herbal formula Dohongsamul-tang (DHT) for its protective effects in a rat model of MI.
  • Rats treated with DHT showed significant improvements in heart function, including increased heart ejection fraction and reduced heart size and infarct area compared to the control group.
  • The treatment also lowered key heart failure biomarkers and indicated changes at the molecular level, suggesting that DHT may help protect the heart by affecting specific signaling pathways.
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Background: Oryeongsan (Wulingsan, Goreisan) has long been used for the treatment of impaired body fluid metabolism. However, the action mechanisms have not been clearly defined. Recently, effects of Oryeongsan on the body fluid and Na metabolism and the action mechanisms have been shown more clearly.

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Background: Investigating the effects of electroacupuncture (EA) treatment on cardiovascular function and aortic lipid profiles in spontaneously hypertensive rats (SHR) constitutes the foundational focus of this study. The overarching goal is to comprehensively elucidate the alterations brought about by EA treatment and to assess its potential as an alternative therapy for hypertension.

Methods: Consecutive EA treatments were administered to SHR, and the effects on systolic blood pressure, cardiac function, and hypertension-related neuronal signals were assessed.

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Background: Herbal medicine Oryeongsan (ORS), also known as Wulingsan in Chinesehas been used for the treatment of impaired body fluid balance. However, the mechanisms involved are not clearly defined. The purpose of the present study was to identify the actions of ORS on the renal excretory function and blood pressure (BP) and to define the mechanisms involved in association with renin-angiotensin system (RAS) and natriuretic peptide system (NPS) in spontaneously hypertensive rats (SHR), an animal model of human essential hypertension.

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Cardiac hypertrophy is developed by various diseases such as myocardial infarction, valve diseases, hypertension, and aortic stenosis. Sibjotang (, Shizaotang, SJT), a classic formula in Korean traditional medicine, has been shown to modulate the equilibrium of body fluids and blood pressure. This research study sought to explore the impact and underlying process of Sibjotang on cardiotoxicity induced by DOX in H9c2 cells.

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  • Dohongsammul-tang (DH) is a traditional Korean herbal medicine known for alleviating symptoms from blood stagnation and protecting against cardiovascular issues.
  • The study aims to investigate DH's potential in reducing cardiac hypertrophy, which is a condition that thickens the heart due to pressure overload, ultimately affecting heart health.
  • The methodology involved creating a concentrated DH extract from six herbal components, which was then tested in a surgical model inducing pressure overload to evaluate its effects on cardiac injury and fibrosis.
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  • Respiratory exposure to particulate matter, particularly fine particulate matter (PM2.5) and diesel exhaust, leads to oxidative stress and inflammation in the lungs, increasing the risk of cardiovascular diseases.
  • The study investigated the effects of Securiniga suffruticosa (S. suffruticosa) on lung and cardiovascular inflammation induced by diesel exhaust particulate (DEP) in mice, finding that S. suffruticosa significantly reduced various inflammatory markers in the lungs and thoracic aorta.
  • The results suggested that S. suffruticosa may offer therapeutic benefits by lowering inflammation and oxidative stress in air pollution-exposed tissues by suppressing the NLRP3 signaling pathway.
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Animal models have been utilized to understand the pathogenesis of Zellweger spectrum disorders (ZSDs); however, the link between clinical manifestations and molecular pathways has not yet been clearly established. We generated peroxin 5 homozygous mutant zebrafish (pex5) to gain insight into the molecular pathogenesis of peroxisome dysfunction. pex5 display hallmarks of ZSD in humans and die within one month after birth.

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Acute kidney injury (AKI) is a major side effect of cisplatin, a crucial anticancer agent. Therefore, it is necessary to develop drugs to protect against cisplatin-induced nephrotoxicity. Ojeoksan (OJS), a traditional blended herbal prescription, is mostly used in Korea; however, there are no reports on the efficacy of OJS against cisplatin-induced AKI.

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  • Oryeongsan (ORS) is an herbal formula used in Asia to treat body fluid and salt imbalances, but its exact mechanism in improving these conditions is not well understood.
  • A study on hypertensive rats revealed that ORS administration led to increased urine production and improved kidney function by affecting specific renal proteins and hormones.
  • ORS treatment also resulted in lower blood pressure by altering the renin-angiotensin system (RAS) and increasing levels of beneficial hormones, suggesting a complex interaction that helps regulate blood pressure and fluid balance.
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  • * Sinkihwan-gamibang (SKHGMB), from traditional Chinese medicine, was studied for its effects on kidney dysfunction in a rat model of NS induced by puromycin aminonucleoside (PAN).
  • * The study found that SKHGMB reduced kidney size, proteinuria, and fluid retention while improving kidney function markers, indicating its potential to combat renal inflammation and fibrosis in NS.
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Oryeongsan (ORS), a herbal medicine formula, has long been used for the treatment of impaired body water balance in Asian countries. Recently, it was shown that ORS administration modulates the renin-angiotensin system (RAS). Purpose of the present study was to determine characteristics of atrial ANP secretion and effects of ORS on the secretion in the atria from spontaneously hypertensive rats (SHR).

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  • Safflower (L.) has historical uses in treating vascular issues related to the heart, brain, and diabetes, and this study explores its potential in reducing vascular inflammation in human cells.
  • The ethanol extract of safflower (ECT) was found to lower the adhesion of leukocytes and reduce key cell adhesion molecules, indicating a protective effect on blood vessel health.
  • ECT also decreases oxidative stress and suppresses harmful signaling pathways, suggesting it could be a promising natural treatment for vascular inflammation, but more research is needed to identify the most effective compounds.
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Samchulkunbi-tang (SCT, Shen Zhu Jian pi tang in Chinese) is said to have been first recorded by Zheng Zhi Zhun Sheng during the Ming Dynasty in China. Records of SCT in Korea are known to have been cited in Donguibogam (Dong Yi Bao Jian in Chinese), Uibang Hwaltu (Yi Fang Huo Tao in Chinese), and Bang Yak Hapyeon (Fang Yao He Bian in China). Although SCT is widely used in treating chronic gastritis and gastric ulcers, the beneficial effect on renal vascular function is unknown.

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  • Diabetic cardiovascular dysfunction is a serious complication of type 2 diabetes, driven by inflammation and myocardial fibrosis, leading to heart structure and function issues.
  • A study compared different mouse groups, including those with type 2 diabetes, and found that blackcurrant extract (Bla.C) improved blood sugar levels and heart function, reducing biomarkers for fibrosis and inflammation.
  • The findings suggest that Bla.C may help prevent cardiovascular complications in diabetes by addressing inflammation and improving overall heart health, highlighting its potential therapeutic value.
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  • Renal ischemia-reperfusion (I/R) injury is a significant cause of acute renal failure, and the study investigates the effects of Geumgwe-sinkihwan (GSH), a traditional Chinese medicine, on a mouse model of this condition.
  • The experiment involved administering different doses of GSH to mice after inducing I/R injury through surgical clamping of renal arteries, revealing that GSH improves kidney function and reduces markers of renal injury.
  • The results showed that GSH decreases inflammatory cytokines and inflammasome-related proteins, suggesting its potential as a therapeutic agent to mitigate renal damage and inflammation in cases of acute renal failure.
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Cardiac hypertrophy can lead to congestive heart failure and is a leading cause of morbidity and mortality worldwide. In recent years, it has been essential to find the treatment and prevention of cardiac hypertrophy. Betulinic acid (BA), the main active ingredient in many natural products, is known to have various physiological effects.

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  • - YG-1 extract was tested for its ability to dilate bronchi and relieve lung inflammation, showing it increases cAMP levels through the β2-adrenergic receptor during ex vivo tests on bronchial tissue.
  • - In vivo experiments on mice revealed that YG-1 extract mitigates acute bronchial and pulmonary inflammation caused by exposure to fine particulate matter (PM2.5) by inhibiting inflammatory cytokines via the NLRP3/caspase-1 pathway.
  • - The study suggests that YG-1 extract has potential as a therapeutic agent for respiratory diseases, providing promising data for future treatments aimed at improving lung function and reducing respiratory symptoms.
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  • The study investigates the effects of an herbal formula called Ma Huang Tang (MHT) on hypertension in rats induced by a substance known as L-NAME.
  • MHT was found to promote vascular relaxation and normalize blood pressure, potentially through the activation of the nitric oxide/cGMP signaling pathway.
  • Additionally, MHT improved kidney function and restored the response of blood vessels to regulatory substances like acetylcholine, indicating its potential benefits for hypertensive patients.
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Progressive diabetic nephropathy (DN) in diabetes leads to major morbidity and mortality. The major pathological alterations of DN include mesangial expansion, extracellular matrix alterations, tubulointerstitial fibrosis, and glomerular sclerosis. is widely used in traditional oriental medicine and has long been used as a diuretic, astringent, insecticide and antihypertensive.

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Joa-gui em (, JGE) is known to be effective for treating kidney-yin deficient syndrome. However, there is a lack of objective pharmacological research on improving kidney function. This study was designed to evaluate whether JGE improves renal function and related mechanisms in rats with acute renal injury induced by ischemia/reperfusion (I/R).

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Cisplatin is the most widely used chemotherapeutic agent. However, it often causes nephrotoxicity, which results in acute kidney injury (AKI). Therefore, we urgently need a drug that can reduce the nephrotoxicity induced by cisplatin.

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Cardiac hypertrophy is a major risk factor for heart failure and leads to cardiovascular morbidity and mortality. Doxorubicin (DOX) is regarded as one of the most potent anthracycline antibiotic agents; however, its clinical usage has some limitations because it has serious cardiotoxic side effects such as dilated cardiomyopathy and congestive heart failure. Betulinic acid (BA) is a pentacyclic-cyclic lupane-type triterpene that has been reported to have anti-bacterial, anti-inflammatory, anti-vascular neogenesis, and anti-fibrotic effects.

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