IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases.

Interleukin-4 (IL-4)-induced T helper (Th) 2 cells promote susceptibility to the protozoan parasite , while conferring immunity to the intestinal trematode Here, we report that abrogation of IL-4 receptor alpha (IL-4Rα) signaling on B cells in BALB/c mice (IL-4Rα) transformed nonhealer BALB/c to a healer phenotype with an early type 1 and dramatically reduced type 2 immune response and an absence of ulceration and necrosis during cutaneous leishmaniasis. From adoptive reconstitution and mixed bone-marrow chimera studies in B cell-deficient (µMT) mice, we reveal a central role for B cell-derived IL-4 and IL-4Rα in the optimal induction of the susceptible type 2 phenotype to infection. We further demonstrate that the absence of IL-4Rα signaling on B cells exacerbated -induced mortality and pathology in BALB/c mice, due to a diminished type 2 immune response.