Navigating the Diagnostic Challenges of Posterior Circulation Ischaemic Strokes: A Case Report of Delayed Diagnosis.

Posterior circulation infarcts (POCI) can present with non-specific symptoms, making diagnosis challenging and often delayed. We present a 58-year-old lady with a history of migraine who attended the emergency department of a district general hospital with sudden onset of vertigo, nausea, and vomiting but without focal neurological deficits. At the initial assessment, she experienced marked dizziness, which was worse on opening her eyes.

Nicotine given intracerebroventricularly does not inhibit the preovulatory surge of LH and PRL secretion in female rats.

To determine the effect of nicotine on LH and PRL secretion, nicotine bitartrate (nicotine) dissolved in saline was administered at 1400 h, just before the critical period for the preovulatory surge of LH and PRL secretion, either intracerebroventricularly (icv) or intravenously (iv) in female rats in proestrus. Nicotine neither at a dose of 5 microg nor at a dose of 10 microg injected icv at 1400 h caused significant changes in the surge of LH and PRL secretion. When nicotine was given iv at a dose of 100 microg, a significant decrease in LH and PRL concentrations occurred immediately, lasting for 2 h.