Accuracy Assessment of SUV Measurements in SPECT/CT: A Phantom Study.

Advances in iterative image reconstruction enable absolute quantification of SPECT/CT studies by incorporating compensations for collimator-detector response, attenuation, and scatter. This study aimed to assess the quantitative accuracy of SPECT/CT based on different levels of Tc activity (low/high) using different SUV metrics (SUV, SUV, SUV, and SUV [the average values that include pixels greater than 60% and 75% of the SUV in the volume of interest, respectively]). A Jaszczak phantom equipped with 6 fillable spheres was set up with low and high activity ratios of 1:4 and 1:10 (background-to-sphere) on background activities of 10 and 60 kBq/mL, respectively.