Publications by authors named "Hiu Kwan Carolyn Tang"

Article Synopsis
  • Immune therapies like anti-CTLA4 and anti-PD1 monoclonal antibodies are improving long-term survival rates for advanced melanoma patients by achieving durable remissions in 50-60% of cases.
  • Despite the high prevalence of brain metastases in advanced melanoma, most clinical trials exclude these patients, making it difficult to assess how effective immunotherapy is for them.
  • Retrospective studies indicate that immunotherapy improves overall survival for melanoma patients with brain metastases compared to supportive care, and combining it with radiotherapy enhances survival outcomes, though symptomatic lesions may respond less effectively.*
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Although exponential progress in treating advanced malignancy has been made in the modern era with immune checkpoint blockade, survival outcomes remain suboptimal. Cellular immunotherapy, such as chimeric antigen receptor T cells, has the potential to improve this. CAR T cells combine the antigen specificity of a monoclonal antibody with the cytotoxic 'power' of T-lymphocytes through expression of a transgene encoding the scFv domain, CD3 activation molecule, and co-stimulatory domains.

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Breast cancer treatment involving ionizing radiation causes characteristic radiation dermatitis in the majority of patients. The DNA damaging effects of radiation can rarely predispose to primary inflammatory dermatoses, such as pemphigus vulgaris. In such cases, the disease presents with all the hallmarks of the primary dermatosis, but the eruption is limited to the field of irradiation and is often amenable to treatment.

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Article Synopsis
  • * Using a transgenic mouse model that expresses HPV8, researchers found an increase in the thickness of skin and abnormal proliferation of specific keratinocyte stem cells (Lrig1+), indicating a link between these cells and skin cancer development.
  • * The results suggest that reactivation of β-HPVs in hair follicles contributes to a cycle of cell proliferation and changes in cell markers, ultimately leading to skin cancer, emphasizing the importance of the hair follicle area in this process
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