Publications by authors named "Hitoyasu Nakamura"

Article Synopsis
  • * Intravenous injection of AAV.GT5 resulted in similar liver transduction in both humanized mice and macaques, but it had a low recovery and short half-life due to its positive charge affecting blood interactions.
  • * Enhanced liver transduction was achieved by administering AAV.GT5 directly into the liver, and unlike AAV-Spark100, AAV.GT5 showed a lower tendency to generate neutralizing antibodies, suggesting it
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Joint bleeding and resultant arthropathy are major determinants of quality of life in haemophilia patients. We previously developed a mesenchymal stromal cell (MSC)-based treatment approach for haemophilic arthropathy in a mouse model of haemophilia A. Here, we evaluated the long-term safety of intra-articular injection of lentivirally transduced autologous MSCs in non-human primates.

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